Abcam, ab140682, Anti-PSMD1 antibody

Size: 100µg
Rabbit Polyclonal PSMD1 antibody. Suitable for IP, WB, IHC-Fr and reacts with Human, Mouse samples. Cited in 10 publications. Immunogen corresponding to Synthetic Peptide within Human PSMD1 aa 900 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-Fr, WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human PSMD1 aa 900 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q99460

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Antibody concentration was determined by extinction coefficient: absorbance at 280 nm of 1.4 equals 1.0 mg of IgG., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PSMD1 also known as Proteasome 26S Subunit Non-ATPase 1 plays a mechanical role in protein degradation within cells. It is a component of the 26S proteasome complex which is responsible for degrading ubiquitinated proteins. The molecular mass of PSMD1 is approximately 108 kDa. PSMD1 expresses broadly in various tissues including the liver heart and skeletal muscle suggesting its involvement in basic cellular functions.
Biological function summary
PSMD1 contributes to the regulation of protein homeostasis through its function in the 26S proteasome complex. This multi-protein complex enables the ATP-dependent degradation of ubiquitinated proteins a critical process for maintaining cellular function. The proteasome's activity ensures the removal of damaged or misfolded proteins and regulates concentrations of specific proteins to maintain cellular processes. Its interaction with other proteasome subunits indicates a strong functional integration within this complex.
Pathways
PSMD1 plays a role in the ubiquitin-proteasome pathway a major pathway for protein catabolism. This pathway is critical for various cellular processes including cell cycle regulation and apoptosis. PSMD1 interacts with other subunits in the proteasome such as PSMA1 and PSMB5 to execute its function. Its connection to these pathways highlights its importance in regulating protein turnover and quality control in cells.
PSMD1 has relevance to cancer and neurodegenerative diseases. Dysregulation of the ubiquitin-proteasome pathway wherein PSMD1 is a significant component can lead to aberrant protein accumulation contributing to disease conditions. In cancers altered PSMD1 expression impacts cell proliferation and survival linking it indirectly with tumor-related proteins such as p53. Similarly in neurodegenerative diseases impaired proteasome function involving PSMD1 associates with proteins like tau known for their role in disorders like Alzheimer's disease.