Abcam, ab141071, 10-Hydroxycamptothecin, DNA topoisomerase I inhibitor

Size: 10mg / 50mg
MW 364.4 Da, Purity >99%. DNA topoisomerase I inhibitor (IC 50 = 106 nM). Cytotoxic antitumour compound, more potent than camptothecin (ab120115). In vitro and in vivo activity against a broad spectrum of cancers.
Key facts
CAS number:64439-81-2,
Purity:>99%,
Form:SolidSee storage information,
Molecular weight:364.4 Da,
Molecular formula:C20H16N2O5,
PubChem:4330531,
Nature:Synthetic,
Solubility:Soluble in DMSO to 50 mM,
Biochemical name:(+/-)-10-Hydroxycamptothecin,
Biological description:DNA topoisomerase I inhibitor (IC50 = 106 nM). Cytotoxic antitumour compound, more potent than camptothecin (ab120115). In vitro and in vivo activity against a broad spectrum of cancers.,
Canonical smiles:CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=CC5=C4)O)O,
InChi:InChI=1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3,
InChiKey:HAWSQZCWOQZXHI-UHFFFAOYSA-N,
IUPAC Name:19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months