Abcam, ab141117, PD 173074, FGFR1 and FGFR3 inhibitor

Size: 10mg / 50mg
MW 523.7 Da, Purity >99%. Potent, ATP-competitive fibroblast growth factor receptor 1 (FGFR1) and FGFR3 inhibitor (IC 50 values are 21.5 and 5 nM respectively). Shows little activity at EGFR, InsR, MEK and cPKC. Effectively inhibits angiogenesis in vivo . Also impairs tumor growth and inhibits self-renewal of stem cells.
Key facts
CAS number:219580-11-7,
Purity:>99%,
Form:SolidSee storage information,
Molecular weight:523.7 Da,
Molecular formula:C28H41N7O3,
PubChem:1401,
Nature:Synthetic,
Solubility:Soluble in DMSO to 100 mMSoluble in ethanol to 100 mM,
Biochemical name:1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea,
Biological description:Potent, ATP-competitive fibroblast growth factor receptor 1 (FGFR1) and FGFR3 inhibitor (IC50 values are 21.5 and 5 nM respectively). Shows little activity at EGFR, InsR, MEK and cPKC. Effectively inhibits angiogenesis in vivo. Also impairs tumor growth and inhibits self-renewal of stem cells.,
Canonical smiles:CCN(CC)CCCCNC1=NC2=NC(=C(C=C2C=N1)C3=CC(=CC(=C3)OC)OC)NC(=O)NC(C)(C)C,
InChi:InChI=1S/C28H41N7O3/c1-8-35(9-2)13-11-10-12-29-26-30-18-20-16-23(19-14-21(37-6)17-22(15-19)38-7)25(31-24(20)32-26)33-27(36)34-28(3,4)5/h14-18H,8-13H2,1-7H3,(H3,29,30,31,32,33,34,36),
InChiKey:DXCUKNQANPLTEJ-UHFFFAOYSA-N,
IUPAC Name:1-tert-butyl-3-[2-[4-(diethylamino)butylamino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-The product can be stored for up to 12 months

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Interferon beta Src Glucocorticoid Receptor CSK Estrogen Receptor VEGF Receptor 2 VEGF Receptor 1 Gli3 Androgen Receptor FGFR1 FGFR2 FGFR4 FGFR3 Yes1 and IDH1 represent proteins and receptors playing different mechanical roles. For instance FGFR1 known as Fibroblast Growth Factor Receptor 1 involves signaling pathways controlling cell division and differentiation; it possesses a mass of approximately 115 kDa. FGFR3 another receptor with similar functions is known for its variants like FGFR3 inhibitors impacting certain pathways. These proteins usually express across various tissues playing roles in development and maintenance.
Biological function summary
These targets and proteins serve roles in signal transduction and cellular response. They are part of complexes that help the body react to external signals. For example VEGF Receptors 1 and 2 contribute to angiogenesis and vascular maintenance. FGFR3 interacts with inhibitors influencing bone development and maintenance. Androgen and Estrogen Receptors modulate gene expression in response to hormonal signals affecting diverse physiological processes.
Pathways
Many of these proteins like Src and Yes1 integrate into significant signaling pathways. The MAPK and PI3K/AKT pathways involve multiple targets such as FGFR1 and Glucocorticoid Receptor contributing to cell growth and survival regulation. These pathways often interact with other proteins for coordinated cellular responses allowing complex regulation of different cellular functions.
These proteins connect to certain pathologies through their involvement in critical pathways. For instance FGFR3 and its inhibitors relate to skeletal disorders like achondroplasia. Estrogen Receptor's interaction can link to breast cancer development often alongside Androgen Receptors influencing hormone-driven tumorous growths. Understanding their roles helps in developing targeted therapies for these conditions.