Abcam, ab141224, Vancomycin hydrochloride, Tricyclic glycopeptide antibiotic

Size: 250mg / 1g
MW 1449.2 Da, Purity >95%. Tricyclic glycopeptide antibiotic. Inhibits cell wall synthesis in Gram-positive bacteria. Pharmacologically active in vivo .
Key facts
CAS number:1404-90-6,
Purity:>95%,
Form:SolidSee storage information,
Molecular weight:1449.2 Da,
Molecular formula:C66H75Cl2N9O24,
PubChem:14969,
Nature:Synthetic,
Solubility:Soluble in water to 100 mM,
Biochemical name:Vancomycin,
Biological description:Tricyclic glycopeptide antibiotic. Inhibits cell wall synthesis in Gram-positive bacteria. Pharmacologically active in vivo.,
Canonical smiles:CC1C(C(CC(O1)OC2C(C(C(OC2OC3=C4C=C5C=C3OC6=C(C=C(C=C6)C(C(C(=O)NC(C(=O)NC5C(=O)NC7C8=CC(=C(C=C8)O)C9=C(C=C(C=C9O)O)C(NC(=O)C(C(C1=CC(=C(O4)C=C1)Cl)O)NC7=O)C(=O)O)CC(=O)N)NC(=O)C(CC(C)C)NC)O)Cl)CO)O)O)(C)N)O,
Isomeric smiles:C[C@H]1[C@H]([C@@](C[C@@H](O1)O[C@@H]2[C@H]([C@@H]([C@H](O[C@H]2OC3=C4C=C5C=C3OC6=C(C=C(C=C6)[C@H]([C@H](C(=O)N[C@H](C(=O)N[C@H]5C(=O)N[C@@H]7C8=CC(=C(C=C8)O)C9=C(C=C(C=C9O)O)[C@H](NC(=O)[C@H]([C@@H](C1=CC(=C(O4)C=C1)Cl)O)NC7=O)C(=O)O)CC(=O)N)NC(=O)[C@@H](CC(C)C)NC)O)Cl)CO)O)O)(C)N)O,
InChi:InChI=1S/C66H75Cl2N9O24/c1-23(2)12-34(71-5)58(88)76-49-51(83)26-7-10-38(32(67)14-26)97-40-16-28-17-41(55(40)101-65-56(54(86)53(85)42(22-78)99-65)100-44-21-66(4,70)57(87)24(3)96-44)98-39-11-8-27(15-33(39)68)52(84)50-63(93)75-48(64(94)95)31-18-29(79)19-37(81)45(31)30-13-25(6-9-36(30)80)46(60(90)77-50)74-61(91)47(28)73-59(89)35(20-43(69)82)72-62(49)92/h6-11,13-19,23-24,34-35,42,44,46-54,56-57,65,71,78-81,83-87H,12,20-22,70H2,1-5H3,(H2,69,82)(H,72,92)(H,73,89)(H,74,91)(H,75,93)(H,76,88)(H,77,90)(H,94,95)/t24-,34+,35-,42+,44-,46+,47+,48-,49+,50-,51+,52+,53+,54-,56+,57+,65-,66-/m0/s1,
InChiKey:MYPYJXKWCTUITO-LYRMYLQWSA-N,
IUPAC Name:(1S,2R,18R,19R,22S,25R,28R,40S)-48-[(2S,3R,4S,5S,6R)-3-[(2S,4S,5S,6S)-4-amino-5-hydroxy-4,6-dimethyloxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-22-(2-amino-2-oxoethyl)-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-[[(2R)-4-methyl-2-(methylamino)pentanoyl]amino]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentazaoctacyclo[26.14.2.23,6.214,17.18,12.129,33.010,25.034,39]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34(39),35,37,46,49-pentadecaene-40-carboxylic acid

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Albumin alpha 2a adrenergic receptor also known as ADRA2A is a G protein-coupled receptor with a mass of approximately 50 kDa. This receptor is mainly expressed in the central nervous system including the brain and in peripheral tissues like the pancreas. It binds to catecholamines such as norepinephrine playing a role in regulating various physiological functions. The presence of glycopeptide structures suggests post-translational modifications that can affect the receptor's activity and stability.
Biological function summary
The alpha 2a adrenergic receptor is associated with inhibitory neurotransmitter release and can form part of a receptor complex influencing processes like vasoconstriction and insulin secretion. It also modulates the release of epinephrine and norepinephrine from the adrenal glands impacting blood pressure and stress responses. In pancreatic tissues this receptor's activity influences insulin release illustrating its role in glucose metabolism.
Pathways
Alpha 2a adrenergic receptor functions prominently in the sympathetic nervous system pathways and the regulation of neurotransmitter release. It interacts closely with other adrenergic receptors such as beta adrenergic receptors to maintain cardiovascular homeostasis. The signaling pathways it engages often involve G protein-mediated pathways that influence cyclic AMP levels affecting downstream cellular effects significant for both cardiovascular and metabolic homeostasis.
The alpha 2a adrenergic receptor has been connected to conditions such as hypertension and type 2 diabetes. In hypertension its role in vasoconstriction and neurotransmitter release affects vascular resistance and blood pressure regulation. Studies have noted its interaction with insulin and other metabolic hormones making it a receptor of interest in type 2 diabetes research. Dysregulation of this receptor is under investigation for its contributions to these conditions potentially opening pathways for targeted therapies.