Abcam, ab141405, PP242, mTOR inhibitor

Size: 1mg
MW 308.34 Da, Purity >98%. Potent, selective and ATP-competitive mTOR inhibitor (IC 50 = 8 nM). Inhibits both mTORC1 and mTORC2. Activates ERK via TORC1/eIF-4E/RAF pathway in cancer cells. Selective for mTOR over PI3K family kinases (IC 50 values are 0.1 (p110γ), 0.41 (DNA-PK), 1.27 (p110δ), 1.96 (p110α) and 2.2 (p110β) μM). Anticancer agent. Active in vivo and in vitro .
Key facts
Purity:>98%,
Molecular weight:308.34 Da,
Molecular formula:C16H16N6O,
PubChem:25243800,
Nature:Synthetic,
Solubility:Soluble in DMSO to 25 mM,
Biochemical name:CID 25243800,
Biological description:Potent, selective and ATP-competitive mTOR inhibitor (IC50 = 8 nM). Inhibits both mTORC1 and mTORC2. Activates ERK via TORC1/eIF-4E/RAF pathway in cancer cells. Selective for mTOR over PI3K family kinases (IC50 values are 0.1 (p110γ), 0.41 (DNA-PK), 1.27 (p110δ), 1.96 (p110α) and 2.2 (p110β) μM). Anticancer agent. Active in vivo and in vitro.,
Canonical smiles:CC(C)N1C2=NC=NC(=C2C(=C3C=C4C=C(C=CC4=N3)O)N1)N,
Isomeric smiles:CC(C)N1C2=NC=NC(=C2/C(=C\3/C=C4C=C(C=CC4=N3)O)/N1)N,
InChi:InChI=1S/C16H16N6O/c1-8(2)22-16-13(15(17)18-7-19-16)14(21-22)12-6-9-5-10(23)3-4-11(9)20-12/h3-8,21,23H,1-2H3,(H2,17,18,19)/b14-12+,
InChiKey:MTICIDWIKCANDD-WYMLVPIESA-N,
IUPAC Name:(2E)-2-(4-amino-1-propan-2-yl-2H-pyrazolo[3,4-d]pyrimidin-3-ylidene)indol-5-ol

Product details:
This product is manufactured by BioVision, an Abcam company and was previously called 1658 PP242. 1658-1 is the same size as the 1 mg size of ab141405.

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months