Abcam, ab141775, CRANAD-2, Near-infrared Amyloid-beta fluorescent probe

Size: 5mg / 25mg
MW 410.3 Da, Purity >98%. Near-infrared (NIR) Amyloid-β fluorescent probe. Upon interacting with Amyloid-β aggregates displays a 70-fold increase in fluorescence intensity accompanied by a 90 nm blue shift from 805 to 715 nm. Demonstrates high affinity for amyloid-β aggregates (K d = 38 nM). Detects amyloid-β in vitro and in vivo. Blood-brain barrier permeable. Learn more .
Key facts
CAS number:1193447-34-5,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:410.3 Da,
Molecular formula:C23H25BF2N2O2,
PubChem:90488972,
Nature:Synthetic,
Solubility:Soluble in DMSO to 5 mM (with warming),
Biochemical name:Cranad-2,
Biological description:Near-infrared (NIR) Amyloid-β fluorescent probe. Upon interacting with Amyloid-β aggregates displays a 70-fold increase in fluorescence intensity accompanied by a 90 nm blue shift from 805 to 715 nm. Demonstrates high affinity for amyloid-β aggregates (Kd = 38 nM). Detects amyloid-β in vitro and in vivo. Blood-brain barrier permeable. Learn more,
Canonical smiles:[B-]1(OC(=CC(=CC=C2C=CC(=[N+](C)C)C=C2)O1)C=CC3=CC=C(C=C3)N(C)C)(F)F,
Isomeric smiles:[B-]1(OC(=C/C(=C/C=C2C=CC(=[N+](C)C)C=C2)/O1)/C=C/C3=CC=C(C=C3)N(C)C)(F)F,
InChi:InChI=1S/C23H25BF2N2O2/c1-27(2)20-11-5-18(6-12-20)9-15-22-17-23(30-24(25,26)29-22)16-10-19-7-13-21(14-8-19)28(3)4/h5-17H,1-4H3,
InChiKey:PVXQJYXODFZTBR-UHFFFAOYSA-N,
IUPAC Name:[4-[(2Z)-2-[6-[(E)-2-[4-(dimethylamino)phenyl]ethenyl]-2,2-difluoro-1,3-dioxa-2-boranuidacyclohex-5-en-4-ylidene]ethylidene]cyclohexa-2,5-dien-1-ylidene]-dimethylazanium

Product details:
This product is manufactured by BioVision, an Abcam company and was previously called 2699 CRANAD-2. 2699-25 is the same size as the 25 mg size of ab141775.

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store in the dark, Store under desiccating conditions