Abcam, ab142215, 3-Deazaneplanocin A

Size: 250µg / 1mg
MW 262.26 Da, Purity >98%. Potent S-adenosylhomocysteine hydrolase (SAHH) and histone methyltransferase (HMT) inhibitor. Induces cancer cell selective apoptosis. Shows antitumor effects in vivo .
Key facts
CAS number:102052-95-9,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:262.26 Da,
Molecular formula:C12H14N4O3,
PubChem:73087,
Nature:Synthetic,
Biochemical name:3-Deazaneplanocin,
Biological description:Potent S-adenosylhomocysteine hydrolase (SAHH) and histone methyltransferase (HMT) inhibitor. Induces cancer cell selective apoptosis. Shows antitumor effects in vivo.,
Canonical smiles:C1=CN=C(C2=C1N(C=N2)C3C=C(C(C3O)O)CO)N,
Isomeric smiles:C1=CN=C(C2=C1N(C=N2)[C@@H]3C=C([C@H]([C@H]3O)O)CO)N,
InChi:InChI=1S/C12H14N4O3/c13-12-9-7(1-2-14-12)16(5-15-9)8-3-6(4-17)10(18)11(8)19/h1-3,5,8,10-11,17-19H,4H2,(H2,13,14)/t8-,10-,11+/m1/s1,
InChiKey:OMKHWTRUYNAGFG-IEBDPFPHSA-N,
IUPAC Name:(1S,2R,5R)-5-(4-aminoimidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol

Product details:
This product is manufactured by BioVision, an Abcam company and was previously called 2060 3-Deazaneplanocin A. 2060-250 is the same size as the 250 μg size of ab142215.

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
S-Adenosylhomocysteine hydrolase also known as SAHH plays a critical mechanical role in cellular metabolism. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (SAH) to homocysteine and adenosine. This enzyme approximately 48 kDa in mass is ubiquitously expressed in most tissues highlighting its universal importance in biological systems. SAHH maintains the cellular methylation balance by regulating the concentrations of SAH a byproduct of methylation reactions.
Biological function summary
S-Adenosylhomocysteine hydrolase acts as an important player in the methylation processes within the cell. By breaking down SAH it ensures proper methylation of DNA proteins and lipids through the recycling of homocysteine and adenosine. SAHH operates as a homotetramer forming a complex essential for its enzymatic function. The balance maintained by SAHH in cellular methylation allows for proper gene expression and signal transduction within various cellular processes.
Pathways
S-Adenosylhomocysteine hydrolase plays an essential role in the methionine cycle and one-carbon metabolism pathways. These pathways are interconnected with the folate cycle important for nucleotide synthesis and cellular methylation. SAHH works with enzymes like methionine synthase and adenosylmethionine linking it to regulation of homocysteine levels. These interconnections are fundamental for maintaining cellular function and homeostasis.
S-Adenosylhomocysteine hydrolase dysregulation can have significant implications. Hyperhomocysteinemia a condition characterized by high levels of homocysteine in the blood often results from SAHH dysfunction leading to cardiovascular diseases. Additionally aberrant SAHH activity connects to certain types of cancer as altered methylation patterns can disrupt normal cell proliferation. The interplay of SAHH with other proteins such as methylenetetrahydrofolate reductase (MTHFR) illustrates the complex network within which this enzyme operates affecting disease outcomes.