Abcam, ab144471, (R)-Flurbiprofen (Tarenflurbil), gamma-secretase inhibitor

Size: 100mg / 500mg
MW 244.26 Da, Purity >99%. γ-secretase inhibitor. Flurbiprofen (ab142877) enantiomer. Inactive towards COX. Inhibits NF-κB and AP-1 activation. Prevents Aβ42 formation and shows anti-inflammatory and neuroprotective effects in vivo. Orally active.
Key facts
CAS number:51543-40-9,
Purity:>99%,
Form:SolidSee storage information,
Molecular weight:244.26 Da,
Molecular formula:C15H13FO2,
PubChem:92337,
Nature:Synthetic,
Solubility:Soluble in ethanol to 100 mMSoluble in DMSO to 25 mM,
Biochemical name:Tarenflurbil,
Biological description:γ-secretase inhibitor. Flurbiprofen (ab142877) enantiomer. Inactive towards COX. Inhibits NF-κB and AP-1 activation. Prevents Aβ42 formation and shows anti-inflammatory and neuroprotective effects in vivo. Orally active.,
Canonical smiles:CC(C1=CC(=C(C=C1)C2=CC=CC=C2)F)C(=O)O,
Isomeric smiles:C[C@H](C1=CC(=C(C=C1)C2=CC=CC=C2)F)C(=O)O,
InChi:InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)/t10-/m1/s1,
InChiKey:SYTBZMRGLBWNTM-SNVBAGLBSA-N,
IUPAC Name:(2R)-2-(3-fluoro-4-phenylphenyl)propanoic acid

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
COX2 also known as Cyclooxygenase 2 and Cytochrome P450 2C19 is an enzyme that has mass approximately 72 kDa. It plays a vital role in converting arachidonic acid to prostaglandins which are lipid compounds that have hormone-like effects. COX2 is inducible and prominently expressed in sites of inflammation epithelial tissues and some cancers. It is not usually present in most normal tissues but becomes highly expressed in response to inflammatory stimuli.
Biological function summary
COX2 is involved in generating prostaglandins influencing inflammation pain and fever response. The enzyme does not typically act alone; it often associates as part of a larger complex that includes other signaling molecules that regulate the conversion of unsaturated fatty acids. This conversion results in substances that can modulate cellular activities such as vasodilation and cellular proliferation. COX2's biological activity links to various body processes that manage inflammation and healing.
Pathways
COX2 is an important enzyme in the prostaglandin biosynthesis pathway and the inflammatory response pathway. Its activity contributes significantly to the biosynthesis of prostanoids which include prostaglandins and thromboxanes. COX2 interacts with and is regulated by inflammatory and mitogenic signals. It shares roles in these pathways with enzymes like COX1 and it often works in concert with phospholipase A2 which releases arachidonic acid for conversion into prostaglandins.
COX2 is notably implicated in inflammatory diseases such as arthritis and plays a role in cancer where its expression is upregulated. The inflammatory processes it facilitates can exacerbate arthritis symptoms making it a target for nonsteroidal anti-inflammatory drugs like ibuprofen and flurbiprofen. In cancer COX2 is associated with increased angiogenesis and tumor growth. The enzyme's pathway intersects with proteins like matrix metalloproteinases in these disease states showing its role in tissue remodeling and neoplastic progression.