Abcam, ab144472, LY255283, BLT2 receptor antagonist

Size: 1mg / 5mg / 10mg / 25mg
MW 360.5 Da, Purity >98%. Selective, competitive BLT2 receptor antagonist (IC 50 values are 1 and 10 μM for BLT2 and BLT1 respectively). Shows antiasthmatic effects in vivo. Orally active.
Key facts
CAS number:117690-79-6,
Purity:>98%,
Molecular weight:360.5 Da,
Molecular formula:C19H28N4O3,
PubChem:122023,
Nature:Synthetic,
Solubility:Soluble in ethanol to 25 mMSoluble in DMSO to 100 mM,
Biochemical name:1-[5-Ethyl-2-hydroxy-4-[[6-methyl-6-(1H-tetrazol-5-YL)heptyl]oxy]phenyl]ethanone,
Biological description:Selective, competitive BLT2 receptor antagonist (IC50 values are 1 and 10 μM for BLT2 and BLT1 respectively). Shows antiasthmatic effects in vivo. Orally active.,
Canonical smiles:CCC1=CC(=C(C=C1OCCCCCC(C)(C)C2=NNN=N2)O)C(=O)C,
InChi:InChI=1S/C19H28N4O3/c1-5-14-11-15(13(2)24)16(25)12-17(14)26-10-8-6-7-9-19(3,4)18-20-22-23-21-18/h11-12,25H,5-10H2,1-4H3,(H,20,21,22,23),
InChiKey:WCGXJPFHTHQNJL-UHFFFAOYSA-N,
IUPAC Name:1-[5-ethyl-2-hydroxy-4-[6-methyl-6-(2H-tetrazol-5-yl)heptoxy]phenyl]ethanone

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The leukotriene B4 receptor also known as BLT BLT1 or leukotriene B4 receptor 2 is a G-protein coupled receptor that mediates the effects of the lipid mediator leukotriene B4 (LTB4). These receptors are widely expressed in leukocytes particularly in neutrophils monocytes and some lymphocytes. The receptor plays a role in immune response by binding to LTB4 a potent chemoattractant which leads to leukocyte recruitment and activation. While the precise molecular weight of the receptor varies between studies it typically falls around 40 kDa.
Biological function summary
Leukotriene B4 and its receptor orchestrate essential roles in the immune system. The receptor forms part of larger receptor complexes that aid in the signaling cascades necessary for immune functions. Through the binding of leukotriene B4 BLT receptor complexes initiate responses such as leukocyte chemotaxis vascular permeability and adhesion to endothelial cells. These processes highlight the receptor's pivotal role in inflammatory responses making it an important player in the regulation of immunity and inflammation.
Pathways
BLT receptors significantly participate in the arachidonic acid pathway contributing to the biosynthesis and action of leukotrienes. This pathway involves several other proteins such as 5-lipoxygenase which aids in the formation of leukotriene precursors. Additionally BLT receptors connect within the MAPK signaling pathway further highlighting their importance in cell survival and proliferation processes. These pathways exemplify how BLT receptors intertwine with broader signaling networks to influence physiological and pathological responses.
Leukotriene B4 and its receptors correlate strongly with inflammatory conditions like asthma and rheumatoid arthritis. The receptor's activation is associated with heightened inflammatory responses making it a relevant target for therapeutic intervention in these ailments. Moreover the receptor shares pathways with other proteins such as cyclooxygenase-2 (COX-2) linking it to disorders where inflammation is a central component. Understanding these connections offers potential for developing treatments that address the dysregulated inflammatory responses in these diseases.