Abcam, ab144515, S14-95, JAK/STAT pathway inhibitor

Size: 500µg
MW 450.6 Da, Purity >95%. JAK/STAT pathway inhibitor. Inhibits IFN-γ mediated expression of the reporter gene (IC 50 values are 5.4 - 10.8 μM). Inhibits COX-2 and NOS II expression (IC 50 = 10.8 μM). Inhibits iNOS-dependent NO production.
Key facts
CAS number:419532-92-6,
Purity:>95%,
Form:LyophilizedSee storage information,
Source:Isolated from Penicillium sp.,
Molecular weight:450.6 Da,
Molecular formula:C28H34O5,
PubChem:10983241,
Nature:Native,
Solubility:Soluble in Methanol.,
Biochemical name:Phenylpyropene C,
Biological description:JAK/STAT pathway inhibitor. Inhibits IFN-γ mediated expression of the reporter gene (IC50 values are 5.4 - 10.8 μM). Inhibits COX-2 and NOS II expression (IC50 = 10.8 μM). Inhibits iNOS-dependent NO production.,
Canonical smiles:CC(=O)OC1CCC2(C(C1(C)C)CCC3(C2CC4=C(O3)C=C(OC4=O)C5=CC=CC=C5)C)C,
Isomeric smiles:CC(=O)O[C@H]1CC[C@]2([C@H](C1(C)C)CC[C@@]3([C@@H]2CC4=C(O3)C=C(OC4=O)C5=CC=CC=C5)C)C,
InChi:InChI=1S/C28H34O5/c1-17(29)31-24-12-13-27(4)22(26(24,2)3)11-14-28(5)23(27)15-19-21(33-28)16-20(32-25(19)30)18-9-7-6-8-10-18/h6-10,16,22-24H,11-15H2,1-5H3/t22-,23+,24-,27-,28+/m0/s1,
InChiKey:MIBRSIZECYPMLX-KZEXJIRGSA-N,
IUPAC Name:[(1R,2S,5S,7R,10R)-2,6,6,10-tetramethyl-16-oxo-14-phenyl-11,15-dioxatetracyclo[8.8.0.02,7.012,17]octadeca-12(17),13-dien-5-yl] acetate

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months