Abcam, ab144532, Suberoyl bis-hydroxamic acid (SBHA), HDAC inhibitor

Size: 100mg / 500mg
MW 204.22 Da, Purity >98%. Potent, non-selective HDAC inhibitor (ID 50 values are 0.25 and 0.3 μM for HDAC1 and HDAC3 respectively). Potentiates the cytostatic effects of 5-Fluorouracil (ab142387). Induces apoptosis. Shows antiproliferative effects (IC 50 = 15 μM, HeLa cells).
Key facts
CAS number:38937-66-5,
Purity:>98%,
Molecular weight:204.22 Da,
Molecular formula:C8H16N2O4,
PubChem:5173,
Nature:Synthetic,
Solubility:Soluble in water to 100 mMSoluble in DMSO to 100 mM,
Biochemical name:n,n'-Dihydroxyoctanediamide,
Biological description:Potent, non-selective HDAC inhibitor (ID50 values are 0.25 and 0.3 μM for HDAC1 and HDAC3 respectively). Potentiates the cytostatic effects of 5-Fluorouracil (ab142387). Induces apoptosis. Shows antiproliferative effects (IC50 = 15 μM, HeLa cells).,
Canonical smiles:C(CCCC(=O)NO)CCC(=O)NO,
InChi:InChI=1S/C8H16N2O4/c11-7(9-13)5-3-1-2-4-6-8(12)10-14/h13-14H,1-6H2,(H,9,11)(H,10,12),
InChiKey:IDQPVOFTURLJPT-UHFFFAOYSA-N,
IUPAC Name:N,N'-dihydroxyoctanediamide

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-Ambient, Appropriate long-term storage conditions-Ambient, Storage information-The product can be stored for up to 12 months

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HDAC1 HDAC2 HDAC3 HDAC4 HDAC6 and HDAC8 are members of the histone deacetylase family involved in removing acetyl groups from histones which leads to chromatin condensation and transcriptional repression. These enzymes have different molecular weights: HDAC1 at 55 kDa HDAC2 at 55 kDa HDAC3 at 49 kDa HDAC4 at 119 kDa HDAC6 at 131 kDa and HDAC8 at 44 kDa. They are widely expressed in various tissues including the brain liver and heart impacting many cellular functions. These enzymes also go by alternate names such as RPD3-like protein for HDAC1.
Biological function summary
These HDACs play important roles in regulating gene expression by forming multi-protein complexes. They interact with other proteins to modulate DNA accessibility influencing transcriptional outcomes. HDACs often associate with transcription factors and co-repressors such as SMRT and N-CoR to stabilize the transcriptional machinery. As a result they impact cell cycle regulation apoptosis and differentiation. These activities highlight their participation in controlling several essential cellular processes.
Pathways
HDACs integrate into key biological pathways such as the MAPK/ERK pathway and the PI3K/AKT pathway. They control cellular responses to external stimuli and help maintain homeostasis. Through these pathways HDACs interact with proteins like p53 a tumor suppressor and RB1 a regulator of cell cycle progression. Their involvement in these pathways emphasizes their essential role in cellular growth and survival linking them to cellular stress responses and oncogenic processes.
HDACs have strong connections to cancer and neurodegenerative diseases. Abnormal HDAC activity contributes to cancer by modulating the expression of oncogenes and tumor suppressor genes with p53 and Myc being key related proteins. In neurodegenerative disorders such as Alzheimer's disease HDAC dysregulation affects gene expression profiles important for neuronal survival with tau protein being a significant associated protein. This connection to diseases reflects the potential of HDACs as therapeutic targets for modulating these pathological conditions.