Abcam, ab144821, Dorsomorphin dihydrochloride, AMP-kinase inhibitor

Size: 5mg / 10mg / 50mg
MW 472.4 Da, Purity >99%. Potent, selective, reversible AMP-kinase inhibitor (K i = 109 nM). BMP type I receptor inhibitor. Induce autophagy in cancer cells independent of AMPK inhibition. Promotes cardiomyogenesis in embryonic stem cells. Reduces hepcidin, VCAM-1 and ICAM-1 expression in vivo. .
Key facts
CAS number:1219168-18-9,
Purity:>99%,
Form:SolidSee storage information,
Molecular weight:472.4 Da,
Molecular formula:C24H27Cl2N5O,
PubChem:49761481,
Nature:Synthetic,
Solubility:Soluble in water to 100 mM,
Biochemical name:Dorsomorphin dihydrochloride,
Biological description:Potent, selective, reversible AMP-kinase inhibitor (Ki = 109 nM). BMP type I receptor inhibitor. Induce autophagy in cancer cells independent of AMPK inhibition. Promotes cardiomyogenesis in embryonic stem cells. Reduces hepcidin, VCAM-1 and ICAM-1 expression in vivo.,
Canonical smiles:C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3.Cl.Cl,
InChi:InChI=1S/C24H25N5O.2ClH/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20;;/h4-11,16-18H,1-3,12-15H2;2*1H,
InChiKey:RJDVIJJQKMGPMV-UHFFFAOYSA-N,
IUPAC Name:6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine;dihydrochloride

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions