Abcam, ab145628, 3-Deazaneplanocin A hydrochloride (DZNep), Lysine methyltransferase EZH2 inhibitor

Size: 250µg / 1mg
MW 298.72 Da, Purity >98%. Lysine methyltransferase EZH2 inhibitor. Competitive s-adenosylhomocysteine hydrolase inhibitor (K i = 50 pM). DZNep acts as an epigenetic modifier, specifically blocking trimethylation of lysine 27 on histone H3 and lysine 20 on histone H4. (Miranda et al., Tan et al., Tseng et al.) Induces cancer cell selective apoptosis. Adenosine (ab120498) analog. Inhibits self-renewal of glioblastoma multiforme cancer stem cells (Suva et al.). Inhibits survival of acute myeloid leukemia blast cells, in combination with a histone deacetylase inhibitor (Fiskus et al.). Enables chemical reprogramming of mouse embryonic fibroblasts iPSC, in combination with CHIR99021 (ab120890), Forskolin (ab120058), Valproic Acid (ab120745), Tranylcypromine (ab120606) and E-616452 (ab142139), by increasing OCT4 expression at later stages of reprogramming (Hou et al.).
Key facts
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:298.72 Da,
Molecular formula:C12H15ClN4O3,
PubChem:358176,
Nature:Synthetic,
Solubility:Soluble in water to 10 mMSoluble in DMSO to 10 mM,
Biochemical name:3-Deazaneplanocin hydrochloride,
Biological description:Lysine methyltransferase EZH2 inhibitor. Competitive s-adenosylhomocysteine hydrolase inhibitor (Ki = 50 pM). DZNep acts as an epigenetic modifier, specifically blocking trimethylation of lysine 27 on histone H3 and lysine 20 on histone H4. (Miranda et al., Tan et al., Tseng et al.) Induces cancer cell selective apoptosis. Adenosine (ab120498) analog. Inhibits self-renewal of glioblastoma multiforme cancer stem cells (Suva et al.).Inhibits survival of acute myeloid leukemia blast cells, in combination with a histone deacetylase inhibitor (Fiskus et al.). Enables chemical reprogramming of mouse embryonic fibroblasts iPSC, in combination with CHIR99021 (ab120890), Forskolin (ab120058), Valproic Acid (ab120745), Tranylcypromine (ab120606) and E-616452 (ab142139), by increasing OCT4 expression at later stages of reprogramming (Hou et al.).,
Canonical smiles:C1=CN=C(C2=C1N(C=N2)C3C=C(C(C3O)O)CO)N.Cl,
InChi:InChI=1S/C12H14N4O3.ClH/c13-12-9-7(1-2-14-12)16(5-15-9)8-3-6(4-17)10(18)11(8)19;/h1-3,5,8,10-11,17-19H,4H2,(H2,13,14);1H,
InChiKey:UNSKMHKAFPRFTI-UHFFFAOYSA-N,
IUPAC Name:5-(4-aminoimidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol;hydrochloride

Product details:
This product is manufactured by BioVision, an Abcam company and was previously called 2444 3-Deazaneplanocin A hydrochloride. 2444-250 is the same size as the 250 µg size of ab145628.

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months