Abcam, ab145866, SAG hydrochloride, Smo activator

Size: 1mg / 5mg
MW 562.98 g/mol, Purity >98%. Potent Smo activator (EC 50 = 3 nM, NIH 3T3-derived Shh-LIGHT2 cells). Interacts with the heptahelical domain (K d = 59 nM). Behaves as an activator at low concentrations and as an inhibitor at high concentrations. Water soluble version of SAG (ab142160).
Key facts
CAS number:912545-86-9,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:562.98 g/mol,
Molecular formula:C28H28ClN3OS.2HCl,
Nature:Synthetic,
Solubility:Soluble in water to 100 mM,
Biological description:Potent Smo activator (EC50 = 3 nM, NIH 3T3-derived Shh-LIGHT2 cells). Interacts with the heptahelical domain (Kd = 59 nM). Behaves as an activator at low concentrations and as an inhibitor at high concentrations. Water soluble version of SAG (ab142160).,
Isomeric smiles:CL.CL.CN[C@H]1CC[C@@H](CC1)N(CC2CCC(CC2)C3CCNCC3)C(=O)C5SC4CCCCC4C5CL,
InChi:InChI=1S/C28H28ClN3OS.2ClH/c1-30-22-10-12-23(13-11-22)32(28(33)27-26(29)24-4-2-3-5-25(24)34-27)18-19-6-8-20(9-7-19)21-14-16-31-17-15-21;;/h2-9,14-17,22-23,30H,10-13,18H2,1H3;2*1H/t22-,23-;;,
InChiKey:BJJLNIXTQTXWIS-MCXZQIONSA-N,
IUPAC Name:3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide dihydrochloride

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months