Abcam, ab145913, N-(p-Coumaroyl)serotonin, Antibacterial agent

Size: 1mg / 5mg / 10mg / 25mg
MW 322.36 g/mol, Purity >95%. An antioxidative phenolic naturally found in plants, including safflower seed and millet grain. Inhibits the production of proinflammatory cytokines by LPS-stimulated human blood monocytes. It is believed that this inhibition is a result of the partial down-regulation of cytokine mRNA levels and inhibition of NF-κB activation. Ameliorates atherosclerosis in vivo , reducing lesion area in mice and rabbits. Augments fibroblast proliferation, and promotes relaxation of vascular smooth muscle cells in vitro . Functions as an antioxidant, inhibiting the effects of high glucose-induced cell death, caspase-3 activation, and the overproduction of the mitochondrial superoxide.
Key facts
CAS number:68573-24-0,
Purity:>95%,
Form:SolidSee storage information,
Molecular weight:322.36 g/mol,
Molecular formula:C19H18N2O3,
Nature:Synthetic,
Solubility:Soluble in DMF (20 mg/ml)Soluble in DMSO (10 mg/ml)Soluble in Ethanol (10 mg/ml)Soluble in DMF:PBS(pH 7.2)(1:1) (0.5mg/ml)Soluble in DMF (20 mg/ml), DMSO & Ethanol (10 mg/ml) and DMF:PBS(pH 7.2)(1:1) (0.5mg/ml). Insoluble in PBS,
Biological description:An antioxidative phenolic naturally found in plants, including safflower seed and millet grain. Inhibits the production of proinflammatory cytokines by LPS-stimulated human blood monocytes. It is believed that this inhibition is a result of the partial down-regulation of cytokine mRNA levels and inhibition of NF-κB activation. Ameliorates atherosclerosis in vivo, reducing lesion area in mice and rabbits. Augments fibroblast proliferation, and promotes relaxation of vascular smooth muscle cells in vitro. Functions as an antioxidant, inhibiting the effects of high glucose-induced cell death, caspase-3 activation, and the overproduction of the mitochondrial superoxide.,
IUPAC Name:(2E)-N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-3-(4-hydroxyphenyl)prop-2-enamide

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-The product can be stored for up to 12 months