Abcam, ab145921, (2S)-2-Hydroxyglutaric acid, alpha-ketoglutarate-dependent dioxygenase competitive inhibitor

Size: 25mg
MW 148.11 g/mol, Purity >95%. α-hydroxy acid. Normally metabolized to 2-oxoglutarate (α-ketoglutarate) by L-2-hydroxyglutarate dehydrogenases, and mutations in this enzyme cause L-2-hydroxyglutaric aciduria, a neurometabolic disorder. Structurally similar to α-ketoglutarate and competitively inhibits α-ketoglutarate-dependent dioxygenases, including lysine demethylases and DNA hydroxylases.
Key facts
CAS number:13095-48-2,
Purity:>95%,
Molecular weight:148.11 g/mol,
Molecular formula:C5H8O5,
Nature:Synthetic,
Biological description:α-hydroxy acid. Normally metabolized to 2-oxoglutarate (α-ketoglutarate) by L-2-hydroxyglutarate dehydrogenases, and mutations in this enzyme cause L-2-hydroxyglutaric aciduria, a neurometabolic disorder. Structurally similar to α-ketoglutarate and competitively inhibits α-ketoglutarate-dependent dioxygenases, including lysine demethylases and DNA hydroxylases.,
IUPAC Name:(S)-2-Hydroxypentanedioic acid

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months