Abcam, ab14602, Anti-PDE1C/PDE1 antibody

Size: 50µg
Rabbit Polyclonal PDE1C/PDE1 antibody. Suitable for IP, WB, IHC-P and reacts with Mouse, Rat, Human samples. Cited in 9 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human, Mouse,
Applications:IP, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:The antibody does not cross react with PDE1A, PDE1B or other PDEs.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PDE1C also known as phosphodiesterase 1C is an enzyme that mechanically regulates intracellular levels of cyclic nucleotides by hydrolyzing cAMP and cGMP. It has a mass of approximately 85 kDa. You can find PDE1C expression in various tissues including the brain heart and vascular smooth muscle. This expression pattern shows its importance in diverse physiological contexts where cAMP and cGMP act as second messengers.
Biological function summary
PDE1C functions as a calcium/calmodulin-dependent phosphodiesterase integrating signals where calcium levels fluctuate. It belongs to a larger family of phosphodiesterases that help modulate intracellular signaling pathways through cyclic nucleotide metabolism. This enzyme can operate independently or as part of complexes with other proteins which allows it to finely tune cellular response to external stimuli by adjusting cAMP and cGMP concentrations.
Pathways
PDE1C plays a significant role in key biological processes related to cyclic nucleotide signaling. It is particularly important in the regulation of the cardiovascular system by affecting vasodilation and cardiac contractility through pathways involving cAMP and cGMP. The enzyme is also involved in the smooth muscle relaxation pathway. PDE1C also interacts with calcium-dependent pathways to coordinate cellular responses that involve isoforms of proteins like PKG (cGMP-dependent protein kinase) and PKA (cAMP-dependent protein kinase).
Aberrant activity of PDE1C links to conditions such as cardiovascular diseases and certain cancers. Dysregulated expression of PDE1C can alter smooth muscle function and contribute to disorders like hypertension and cardiac hypertrophy. PDE1C also interacts with proteins like VEGF (vascular endothelial growth factor) in cancer biology where it can influence tumor growth and angiogenesis by modifying cellular proliferation through altered cyclic nucleotide signaling.