Abcam, ab146413, CFM 2, AMPA receptor antagonist

Size: 10mg / 50mg
MW 311.33 Da, Purity >98%. Selective, non-competitive AMPA receptor antagonist. ERK1/2 pathway inhibitor. Reduces CREB phosphorylation and shows antiproliferative effects. Shows potent, long-acting anticonvulsant effects in vivo .
Key facts
CAS number:178616-26-7,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:311.33 Da,
Molecular formula:C17H17N3O3,
PubChem:4377504,
Nature:Synthetic,
Solubility:Soluble in DMSO to 100 mM,
Biochemical name:1-(4-Aminophenyl)-7,8-dimethoxy-3,5-dihydro-2,3-benzodiazepin-4-one,
Biological description:Selective, non-competitive AMPA receptor antagonist. ERK1/2 pathway inhibitor. Reduces CREB phosphorylation and shows antiproliferative effects. Shows potent, long-acting anticonvulsant effects in vivo.,
Canonical smiles:COC1=C(C=C2C(=C1)CC(=O)NN=C2C3=CC=C(C=C3)N)OC,
InChi:InChI=1S/C17H17N3O3/c1-22-14-7-11-8-16(21)19-20-17(13(11)9-15(14)23-2)10-3-5-12(18)6-4-10/h3-7,9H,8,18H2,1-2H3,(H,19,21),
InChiKey:MJKADKZSYQWGLL-UHFFFAOYSA-N,
IUPAC Name:1-(4-aminophenyl)-7,8-dimethoxy-3,5-dihydro-2,3-benzodiazepin-4-one

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-Ambient, Appropriate long-term storage conditions-Ambient, Storage information-The product can be stored for up to 12 months

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Cytochrome P450 3A4 commonly known as CYP3A4 is an enzyme with a molecular mass of about 57 kDa. It plays an important role in the metabolism of drugs in the human liver and intestine. Its expression is highest in hepatic and intestinal tissues where it catalyzes the oxidation of small organic molecules. Besides CYP3A4 modifies the chemical structure of drugs and toxins affecting their activity and clearance from the body which is important for drug interaction studies. This modification can significantly impact pharmacokinetics and pharmacodynamics.
Biological function summary
CYP3A4 functions as part of the cytochrome P450 monooxygenase complex which helps with hormone synthesis and metabolism as well as the breakdown of various xenobiotics. It acts in cooperation with NADPH-cytochrome P450 reductase enabling electron transfer necessary for enzymatic reactions. Furthermore the enzyme shows a high degree of overlapping substrate specificity allowing it to metabolize a number of structurally diverse compounds including endogenous and exogenous substances. This flexibility highlights its essential role in hepatic detoxification processes.
Pathways
CYP3A4 is integral to the drug metabolism pathway and the steroid biosynthesis pathway. It interacts with other cytochrome P450 enzymes and transport proteins such as CYP3A5 contributing to the biotransformation of drugs and natural compounds. Its function in these pathways influences the regulation of compound levels in the body impacting drug efficacy and safety. CYP3A4 activity can alter cholesterol homeostasis and the production of biochemically active steroid hormones affecting numerous physiological processes.
CYP3A4 is linked to drug-induced liver injury and cancer. Aberrant expression or mutations can lead to improper drug metabolism causing toxic accumulation and adverse drug reactions. The enzyme is often involved in the metabolic activation of procarcinogens correlating its activity with cancer risk. Additionally its interaction with P-glycoprotein influences the absorption and elimination of chemotherapeutic agents affecting treatment efficacy and patient outcomes. Understanding variations in CYP3A4 activity can aid in personalized medicine approaches to mitigate these risks.