Abcam, ab146666, Quisqualic acid (mM/ml), group I mGlu agonist

Size: 20mM / mL
MW 189.13 Da, Purity >99%. Potent group I mGlu agonist and AMPA receptor agonist. Achieve your results faster with highly validated, pure and trusted compounds.
Key facts
CAS number:52809-07-1,
Purity:>99%,
Form:SolidSee storage information,
Molecular weight:189.13 Da,
Molecular formula:C5H7N3O5,
PubChem:40539,
Nature:Synthetic,
Biochemical name:Quisqualic acid,
Biological description:Potent group I mGlu agonist and AMPA receptor agonist.,
Canonical smiles:C(C(C(=O)O)N)N1C(=O)NC(=O)O1,
Isomeric smiles:C([C@@H](C(=O)O)N)N1C(=O)NC(=O)O1,
InChi:InChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1,
InChiKey:ASNFTDCKZKHJSW-REOHCLBHSA-N,
IUPAC Name:(2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acid

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Glutamate receptors are key components involved in synaptic transmission and neural plasticity. They consist of multiple subtypes including Ionotropic (AMPA NMDA Kainate) and Metabotropic (mGluR) receptors. Notable members include GluA1 GluA3 GluA4 GRIK2/GluK2 GRIK3/GluK3 GluK1 GluK5 and mGluR5. These receptors are located primarily in the central nervous system and are integral to the maintenance of fast excitatory synaptic transmission. These proteins such as GluA1 (AMPA receptor) have molecular masses varying between approximately 90 to 100 kDa and play distinct roles in responding to the neurotransmitter glutamate.
Biological function summary
These receptors drive important processes in neurocommunication and plasticity. They act in both ionotropic capacity mediating fast excitatory transmission through cation flows and metabotropic roles modulating signalling pathways via G-proteins. Receivers like GluA1 form tetrameric complexes facilitating synaptic responses and are important in learning and memory. Metabotropic variants such as mGluR1a and mGluR5 influence synaptic plasticity and development by modulating intracellular signalling cascades. Together these receptors are essential in transmitting the excitatory signals important for normal brain function.
Pathways
These receptors are integral to pathways such as the glutamatergic synapse and neurotrophin signalling pathways. They interact with proteins such as PSD-95 within postsynaptic density where AMPA and NMDA receptors play a synergistic role in synaptic strength. Their interaction allows the fine-tuning of synaptic responses. The Metabotropic receptors are linked to intracellular pathways impacting calcium signalling while the Kainate receptors contribute to the regulation of excitability and neurotransmitter release.
Abnormal functioning of these receptors links to several conditions including Alzheimer's disease and epilepsy. In Alzheimer's dysregulation of GluA1 and NMDA receptors can contribute to synaptic loss and cognitive decline. In epilepsy altered activity of Kainate receptors like GluK2 may lead to increased neuronal excitability and seizure propagation. Targeting these receptors can provide therapeutic strategies for managing these neurological disorders and improving patient outcomes.