Abcam, ab146696, (S)-3,4-DCPG (UBP1109) (mM/ml), mGlu8a agonist

Size: 50mM / mL
MW 239.18 Da, Purity >99%. Potent, selective mGlu8a agonist (EC50 = 31 nM). Displays >100-fold selectivity over mGlu1-7. Systemically active in vivo. Soluble in 1 ml water to give specified mM/ml concentration.
Key facts
CAS number:201730-11-2,
Purity:>99%,
Form:SolidSee storage information,
Molecular weight:239.18 Da,
Molecular formula:C10H9NO6,
PubChem:16062593,
Nature:Synthetic,
Biochemical name:4-[(S)-Amino(carboxy)methyl]benzene-1,2-dicarboxylic acid,
Biological description:Potent, selective mGlu8a agonist (EC50 = 31 nM). Displays >100-fold selectivity over mGlu1-7. Systemically active in vivo. Soluble in 1 ml water to give specified mM/ml concentration.,
Canonical smiles:C1=CC(=C(C=C1C(C(=O)O)N)C(=O)O)C(=O)O,
Isomeric smiles:C1=CC(=C(C=C1[C@@H](C(=O)O)N)C(=O)O)C(=O)O,
InChi:InChI=1S/C10H9NO6/c11-7(10(16)17)4-1-2-5(8(12)13)6(3-4)9(14)15/h1-3,7H,11H2,(H,12,13)(H,14,15)(H,16,17)/t7-/m0/s1,
InChiKey:IJVMOGKBEVRBPP-ZETCQYMHSA-N,
IUPAC Name:4-[(S)-amino(carboxy)methyl]phthalic acid

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The metabotropic glutamate receptor 1a (mGluR1a) along with related subtypes mGluR4 and mGluR8 acts mechanically as a G-protein coupled receptor which modulates neurotransmitter release in the central nervous system (CNS). These receptors bind to glutamate causing signal transduction through G-proteins that lead to changes in intracellular levels of secondary messengers. mGluR1a possesses an approximate molecular mass of 123 kDa and is expressed in regions including the cerebral cortex hippocampus and cerebellum where they play roles in synaptic plasticity and neural communication.
Biological function summary
Metabotropic glutamate receptor activity contributes to the modulation of synaptic transmission and is involved in various neural processes. These receptors do not act as part of larger protein complexes but engage with other proteins to facilitate neurotransmitter signaling and plasticity. They influence numerous functions such as cognition learning and memory by modulating postsynaptic excitability and neurotransmitter release therefore playing significant roles in brain function.
Pathways
Metabotropic glutamate receptors participate significantly in glutamatergic signaling and the phosphoinositide pathway. These pathways are integral to synaptic plasticity and neuronal excitability. mGluR1a interacts with proteins such as Homer and scaffolding proteins to influence their pathways. By affecting these pathways mGluR1a and its subtypes can impact downstream signaling events altering cellular responses and contributing to physiological adaptation in the CNS.
Alterations in mGluR1a function or expression relate to neurological diseases like Parkinson's disease and fragile X syndrome. Changes in mGluR1a signaling affect synaptic communication which can disrupt normal brain function and contribute to such conditions. In these diseases mGluR1a interacts with proteins like FMRP and other glutamate receptors that modulate disease progression and symptom severity. Therefore mGluR1a holds potential importance in understanding and developing therapeutic strategies for these diseases.