Abcam, ab146825, CRT5, protein kinase D inhibitor

Size: 5mg
MW 454.6 Da, Purity >97%. Potent, selective, pyrazine benzamide protein kinase D inhibitor (IC 50 values are 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3 respectively). Blocks phosphorylation of PKD1 on Ser 916 and PKD2 on Ser 876 , but does not affect PKC-dependent PKD phosphorylation. Decreases VEGF-induced endothelial migration, proliferation and tubulogenesis.
Key facts
CAS number:1034297-58-9,
Purity:>97%,
Form:SolidSee storage information,
Molecular weight:454.6 Da,
Molecular formula:C28H30N4O2,
PubChem:58238286,
Nature:Synthetic,
Solubility:Soluble in DMSO to 50 mM,
Biochemical name:Crt5 (crt0066051),
Biological description:Potent, selective, pyrazine benzamide protein kinase D inhibitor (IC50 values are 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3 respectively). Blocks phosphorylation of PKD1 on Ser916 and PKD2 on Ser876, but does not affect PKC-dependent PKD phosphorylation. Decreases VEGF-induced endothelial migration, proliferation and tubulogenesis.,
Canonical smiles:CCOC1=CC2=C(C=C1)C=C(C=C2)C3=C(N=CC(=C3)C4=CC(=CC=C4)C(=O)NCCN(C)C)N,
InChi:InChI=1S/C28H30N4O2/c1-4-34-25-11-10-20-14-22(9-8-21(20)16-25)26-17-24(18-31-27(26)29)19-6-5-7-23(15-19)28(33)30-12-13-32(2)3/h5-11,14-18H,4,12-13H2,1-3H3,(H2,29,31)(H,30,33),
InChiKey:XBDRAUPLGHAFCU-UHFFFAOYSA-N,
IUPAC Name:3-[6-amino-5-(6-ethoxynaphthalen-2-yl)pyridin-3-yl]-N-[2-(dimethylamino)ethyl]benzamide

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions