Abcam, ab150408, Anti-RHOBTB1 antibody [EPR8990]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal RHOBTB1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR8990,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
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Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RHOBTB1 also known as Rho-related BTB domain-containing protein 1 is a member of the Rho GTPase family. It has a molecular mass of approximately 82 kDa. This protein is mainly expressed in the brain and testis with lower levels found in other tissues. RHOBTB1 functions by acting as a molecular switch that cycles between an active GTP-bound state and an inactive GDP-bound state which regulates various cellular processes.
Biological function summary
RHOBTB1 is involved in the regulation of cytoskeletal dynamics which affects cell shape motility and possibly cell division. It is also implicated in intracellular signaling processes that control cell morphology. RHOBTB1 does not function alone; it interacts with other proteins possibly forming part of larger protein complexes that further expand its role in cellular activities.
Pathways
RHOBTB1 plays a role in signaling pathways that include the Rho GTPase cycle and cellular processes related to cytoskeletal reorganization. In these pathways RHOBTB1 interacts with proteins such as CDC42 and RAC1 which are essential for actin filament polymerization and cellular movement. These interactions help facilitate normal cellular dynamics and responses to extracellular signals.
Mutations or dysregulation of RHOBTB1 have been linked to neurological conditions and certain cancers. For example RHOBTB1 abnormalities have been associated with an increased risk of glioblastoma where it might interact with tumor suppressor proteins like p53. Additionally RHOBTB1's role in vacuole formation has implications in lysosomal storage diseases connecting it to other lysosomal proteins involved in these processes.