Abcam, ab150561, Anti-CRF1/CRHR1 antibody

Size: 50µg
Rabbit Polyclonal CRF1/CRHR1 antibody. Suitable for IHC-P and reacts with Rat, Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human CRHR1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human CRHR1. The exact immunogen used to generate this antibody is proprietary information.P34998,
Specificity:BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.1% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CRF1 also known as CRHR1 is a receptor for corticotropin-releasing factor (CRF) a peptide hormone involved in stress response. This receptor is a G protein-coupled receptor with a mass of approximately 50 kDa. CRHR1 is expressed in the central nervous system especially in the brain regions like the cortex and the cerebellum. It can also be found in peripheral tissues like the pituitary gland. Its localization is important because it is involved in mediating the effects of CRF across various tissues.
Biological function summary
CRHR1 plays a significant role in stress-related responses and is involved in the modulation of the hypothalamic-pituitary-adrenal (HPA) axis. When CRF binds to this receptor it triggers the release of adrenocorticotropic hormone (ACTH) from the pituitary gland. CRHR1 is also part of the CRF receptor family complex which includes CRHR2 another receptor with similar functions. The interaction with CRF can initiate various signaling pathways further affecting physiological responses to stress.
Pathways
CRHR1 integrates into the HPA axis pathway as well as the cyclic AMP (cAMP) signaling pathway. In the HPA pathway CRHR1's activation leads to the secretion of ACTH ultimately resulting in cortisol production by the adrenal glands. The cAMP-responsive element-binding protein (CREB) may become activated in response to CRHR1 modulation influencing gene expression and cellular response to stress. The CRHR1 receptor therefore plays a critical role in these pathways by linking stress signals to hormonal and behavioral changes.
CRHR1 has a strong connection to stress-related conditions such as depression and anxiety. Dysregulation in CRHR1 signaling can lead to altered HPA axis functioning which contributes to the development of these disorders. Stress-induced activation of CRHR1 is associated with increased levels of cortisol which is commonly seen in individuals with depression. Furthermore CRHR1 interacts closely with other proteins like the glucocorticoid receptor (GR) which also play a part in these psychiatric conditions indicating a complex network of interactions that govern stress responses.