Abcam, ab150900, Anti-METTL21B antibody

Size: 100µL
Rabbit Polyclonal METTL21B antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human EEF1AKMT3 aa 150 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human EEF1AKMT3 aa 150 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q96AZ1

Product details:
The antibody solution should be gently mixed before use.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
METTL21B also known as EEF1AKMT3 is a methyltransferase enzyme with a molecular weight of approximately 30 kDa. It catalyzes the transfer of a methyl group to its target protein substrates specifically on lysine residues. This methylation process is essential for altering protein interactions and function. METTL21B is mostly expressed in the brain but researchers have also observed its presence in other tissues.
Biological function summary
The methylation activity of METTL21B influences protein stability and cellular localization. It forms part of the methyltransferase family and is involved in modifying proteins by targeting their lysine residues. METTL21B modulates the activity of proteins thereby playing a role in protein maintenance and cellular homeostasis. This protein does not operate alone but may interact with other molecular components to exert its effects.
Pathways
METTL21B participates in regulatory pathways affecting protein translation and degradation. It interacts with components of the translational machinery including proteins involved in elongation processes. METTL21B might influence the protein synthesis pathway and could relate to elongation factors like EEF1A which affects the elongation of peptide chains during translation.
METTL21B's methylation function has ties to certain neurological conditions. Aberrant expression or mutations may link to cognitive disorders as protein modification affects neuronal signaling pathways. The enzyme may interact with proteins involved in neurodegenerative diseases such as Alzheimer's. While the exact mechanisms remain under study its relationship with other methyltransferase enzymes could implicate it in disease progression highlighting METTL21B's potential role in therapeutic interventions.