Abcam, ab150968, Anti-HEATR1 antibody

Size: 100µL
Rabbit Polyclonal HEATR1 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human HEATR1 aa 450-550.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human HEATR1 aa 450-550. The exact immunogen used to generate this antibody is proprietary information.Q9H583

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HEATR1 also known as HEAT repeat-containing protein 1 is a cytoplasmic protein with a molecular mass of approximately 166 kDa. The protein features several HEAT repeats which are tandemly arranged alpha-helical motifs. HEATR1 expresses in various tissues with high levels detected in the testes and lower levels in brain and lungs. The protein plays a role in cellular processes like protein trafficking and folding contributing to ribosome biogenesis and maintenance of cell cycle progression.
Biological function summary
HEATR1 influences pathways involved in the assembly and maturation of the ribosomal machinery. It forms part of the ribosome assembly complex associating with other ribosome biogenesis factors to facilitate ribosome production. The involvement of HEATR1 in the assembly complex helps ensure the ribosomes are correctly formed and functional impacting protein synthesis efficiency.
Pathways
HEATR1 interacts with key regulators in the ribosome biogenesis pathway and is linked to cell cycle regulation. It connects to proteins such as NOP14 and WDR25 within these pathways highlighting its importance in ribosome assembly and cellular division. The accurate functioning of these pathways is critical for cell growth and proliferation affecting overall cellular health and metabolism.
HEATR1 may be related to ribosomopathies and certain cancers where defects in ribosome biogenesis or aberrant protein synthesis play a role. The protein’s interactions with NOP14 suggest potential connections with disorders in ribosome production which may lead to proliferation issues observed in malignancies. Understanding the role of HEATR1 can offer insights into the molecular mechanisms behind these conditions aiding in the development of new therapeutic strategies.