Abcam, ab150971, Anti-SMOX antibody

Size: 100µL
Rabbit Polyclonal SMOX antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SMOX aa 1-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SMOX aa 1-150. The exact immunogen used to generate this antibody is proprietary information.Q9NWM0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SMOX also known as spermine oxidase is an enzyme that catalyzes the oxidation of spermine to spermidine releasing hydrogen peroxide and 3-aminopropanal. This enzyme is important in the polyamine metabolism process. SMOX has a molecular mass of approximately 66 kDa. It is expressed in various tissues including the liver kidney and other tissues with high metabolic activity.
Biological function summary
SMOX is essential for polyamine catabolism influencing cell growth and proliferation. It does not function as part of a complex but works independently to regulate intracellular levels of polyamines. The balance of polyamines like spermine and spermidine is critical for cellular functions impacting cell cycle regulation and apoptosis.
Pathways
The enzymatic activity of SMOX plays an important role in the polyamine metabolic pathway. This pathway interconnects with the urea cycle and is involved in the regulation of cellular proliferation. SMOX influences the activity of proteins like ornithine decarboxylase (ODC) which is vital in polyamine synthesis. By controlling polyamine levels SMOX indirectly modulates signaling pathways associated with cellular responses and stress reactions.
SMOX has a connection with cancer and neurodegenerative diseases. Abnormal expression of SMOX can disrupt polyamine homeostasis leading to oxidative stress and promoting tumorigenesis. In cancer SMOX activity often pairs with increased levels of ODC contributing to tumor progression. In neurodegenerative diseases such as Alzheimer's disease SMOX activity is linked to elevated oxidative stress resulting in neuronal damage and cognitive decline. The regulation of SMOX and polyamine metabolism remains a focus of research for therapeutic strategies.