Abcam, ab151001, Anti-USP54 antibody

Size: 100µL
Rabbit Polyclonal USP54 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human USP54.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human USP54. The exact immunogen used to generate this antibody is proprietary information.Q70EL1

Product details:
The antibody solution should be gently mixed before use.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
USP54 also known as Ubiquitin-Specific Protease 54 is a deubiquitinating enzyme. It is part of the large family of proteases that removes ubiquitin from proteins marked for degradation therefore regulating their stability. The molecular weight of USP54 is approximately 192 kDa. Expression of USP54 occurs in a range of tissues with higher levels seen in some brain areas and liver. It has widespread but varied activity depending on cellular needs and conditions.
Biological function summary
USP54 plays a role in modulating protein turnover and recycling through its deubiquitinating activity. This regulation helps cells maintain balance in protein levels and activity. Unlike some other deubiquitinating enzymes USP54 is not known to be a component of a larger protein complex. However it shares functional similarities with other enzymes in the ubiquitin-proteasome system which orchestrates the targeted degradation of proteins to control cellular processes.
Pathways
USP54 engages in the ubiquitin-proteasome pathway a critical pathway for protein degradation. This pathway ensures timely removal of misfolded or damaged proteins. USP54 may interact with proteins involved in this pathway to fine-tune the degradation process. Within the context of cellular regulatory networks USP54 may also have connections with signaling pathways where regulation of protein levels impacts signaling cascades. For instance proteins like UBE2D3 and UBC are ubiquitin-conjugating enzymes that might be related through shared pathway dynamics.
USP54 exhibits links to certain cancers and neurological disorders. Its role in protein regulation suggests impacts on cancer through protein stability potentially affecting cell growth and survival. Aberrant expression of USP54 may lead to altered degradation of oncogenic proteins. In neurological disorders USP54's higher expression in brain areas might suggest involvement in processes important for neural maintenance or development. The regulatory actions of USP54 might relate to proteins like p53 a known tumor suppressor protein by influencing its degradation and stability in cancer pathways.