Abcam, ab151100, Anti-SPEF1 antibody

Size: 100µL
Rabbit Polyclonal SPEF1 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SPEF1 aa 1-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SPEF1 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.Q9Y4P9

Product details:
The antibody solution should be gently mixed before use.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SPEF1 also known as Sperm Flagellar Protein 1 functions in the motility of cilia and flagella. The protein has a mass of approximately 38 kDa. Researchers have observed its expression mainly in tissues with motile cilia such as the respiratory tract and reproductive system. It is essential for proper ciliary movement contributing to the physical structure and movement capability of cilia and flagella.
Biological function summary
As part of motility mechanisms SPEF1 plays a role in the assembly and stabilization of the axoneme the core structure of cilia and flagella. This protein is an axonemal protein that interacts with microtubules facilitating the sliding of microtubule doublets necessary for ciliary beating. SPEF1 does not act alone; it works within a multi-protein complex that includes other ciliary proteins to ensure effective ciliary and flagellar function.
Pathways
SPEF1 participates in pathways involved in respiratory cilia function and sperm motility. Within these pathways its role is connected to proteins such as dynein and kinesin which are also involved in microtubule-based movements. These pathways are essential for proper respiratory function and fertility due to their involvement in the movement and fluid clearance by cilia as well as sperm motility.
SPEF1 dysregulation links to primary ciliary dyskinesia (PCD) and some infertility cases. PCD results from mutated components of the axoneme impacting SPEF1 along with other proteins like DNAI1. These conditions illustrate the importance of functional ciliary and flagellar proteins for respiratory health and reproduction. Understanding the exact role of SPEF1 in these disorders helps in the development of targeted therapies and diagnostic tools.