Abcam, ab151118, Anti-MRPS14 antibody

Size: 100µL
Rabbit Polyclonal MRPS14 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MRPS14 aa 1 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MRPS14 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O60783

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MRPS14 also known as mitochondrial ribosomal protein S14 is a component of the mitochondrial ribosome small subunit (28S). This protein plays an essential mechanical role in mitochondrial protein synthesis. It has a mass of approximately 16 kDa. MRPS14 is expressed in mitochondria and you find it in cells across a wide range of human tissues. It participates in translation processes specific to the mitochondrial environment showing its critical involvement in cellular energy production.
Biological function summary
Mitochondrial ribosomal protein S14 is vital for the synthesis of proteins that are encoded by mitochondrial DNA. It forms part of the mitochondrial ribosome complex collaborating with other mitochondrial ribosomal proteins to translate mitochondrial mRNA into functional polypeptides. This protein manufacturing process is necessary for the assembly of oxidative phosphorylation complexes which are key components of energy production in cells. The efficient function of MRPS14 is important for maintaining cellular metabolic activity.
Pathways
MRPS14 plays a role in the mitochondrial translation pathway which includes the steps necessary for converting genetic instructions into functional proteins within the mitochondria. It also intersects with the oxidative phosphorylation pathway where it supports energy production by enabling the synthesis of essential respiratory chain proteins. MRPS14 works closely with other mitochondrial ribosomal proteins like MRPS11 and MRPS16 contributing to the assembly and function of the mitochondrial ribosome.
MRPS14 has been linked to mitochondrial dysfunction which is implicated in disorders such as mitochondrial myopathy and MELAS syndrome (Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-like episodes). These conditions typically arise due to disruptions in energy production processes within mitochondria. Interaction with proteins such as MRPL44 and MRPS22 which also play roles in mitochondrial protein synthesis can affect the overall pathological outcomes in mitochondrial diseases.