Abcam, ab151307, Anti-TRIP antibody

Size: 100µL
Rabbit Polyclonal TRIP antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TRAIP aa 150-400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TRAIP aa 150-400. The exact immunogen used to generate this antibody is proprietary information.Q9BWF2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TRIP also known as thyroid hormone receptor interactor protein interacts with the thyroid hormone receptor to modulate its function. TRIP weighs approximately 82 kDa and shows expression in various tissues especially in those with thyroid hormone activity. Researchers identify this protein mainly in the gastrointestinal tract liver and kidneys. Its expression profile suggests that TRIP plays a role in managing local responses to thyroid hormones across the body.
Biological function summary
TRIP influences the regulation and modulation of thyroid hormone receptor activity. It does this by being part of a larger multiprotein complex that assists in gene transcription regulation. This activity is important for controlling metabolic processes and energy balance as the thyroid hormone significantly impacts these areas. TRIP's ability to alter receptor activity suggests that it may serve as an important regulatory node in cellular metabolism potentially impacting growth and development pathways.
Pathways
The interaction of TRIP with thyroid hormone receptors integrates into the thyroid hormone signaling pathway. This pathway is essential for regulating metabolism heart rate and even cognitive function. TRIP is believed to interact with proteins such as PPARs (peroxisome proliferator-activated receptors) which are also important in lipid metabolism. These interactions highlight TRIP’s broad contributions to critical physiological processes and disease modulation.
Researchers find TRIP to have a connection with metabolic disorders and certain cancers. In metabolic syndrome TRIP's modulation of thyroid hormone receptor activity can influence lipid metabolism and contribute to the onset of obesity and type II diabetes. In cancer alterations in TRIP expression or function correlate with abnormal cellular proliferation and tumor progression with connections seen to proteins like TGF-beta which plays a role in cell growth and differentiation.