Abcam, ab151327, Anti-CORO2B antibody

Size: 100µL
Rabbit Polyclonal CORO2B antibody. Suitable for ICC/IF, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CORO2B aa 1-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human CORO2B aa 1-250. The exact immunogen used to generate this antibody is proprietary information.Q9UQ03

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CORO2B also known as Coronin-2B is a protein with a mass of approximately 51 kDa. It belongs to the coronin family and is involved in cellular organization. CORO2B typically expresses in tissues with high concentrations of actin filaments such as neurons and muscle cells. It binds to actin and plays a role in various cellular dynamics processes.
Biological function summary
CORO2B associates with the regulation of cytoskeleton organization. It is part of the actin-binding complex and contributes to actin filament remodeling and stabilization. This protein interacts with other cytoskeletal proteins to modulate the structure and dynamics of the actin network impacting cell movement adhesion and morphology.
Pathways
CORO2B takes part in actin cytoskeleton regulation and the Wnt signaling pathway. It collaborates with other proteins like ARP2/3 complex and cofilin to influence actin filament dynamics. These pathways are essential for maintaining cellular architecture and transmitting signals that direct cell positioning and polarity.
CORO2B shows relevance to neurodegenerative diseases and cancer. Abnormal expression or mutation of CORO2B can disrupt cytoskeletal dynamics contributing to pathological conditions such as Alzheimer's disease. It also interacts with proteins like tau in neurodegenerative contexts and EGFR in cancer progression highlighting its involvement in disease mechanisms.