Abcam, ab151416, Anti-Noelin antibody - C-terminal

Size: 100µL
Rabbit Polyclonal Noelin antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human OLFM1 aa 400 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human OLFM1 aa 400 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q99784

Product details:
The immunogen was raised from noelin isoform 1 precursor(NP_055094)

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Noelin also known as Olfactomedin 1 (OLFM1) is a secreted glycoprotein with a molecular mass around 55 kDa. It is expressed in the central nervous system particularly within the brain and retina and also in some peripheral tissues. The protein plays roles in synaptic function due to its ability to bind to components within the extracellular matrix.
Biological function summary
Noelin contributes to the stabilization of synaptic structures and regulation of neuronal network formation. It interacts with other olfactomedin domain-containing proteins and forms complexes to mediate its functions. These interactions help maintain synaptic plasticity which is important for learning and memory processes.
Pathways
The target takes part in neural development and function. It is involved in the Wnt signaling pathway important for cellular communication in brain development. Noelin also interacts with axon guidance molecules like netrins facilitating proper neuronal network formation. This places Noelin in important roles where fine-tuning synaptic connectivity is necessary.
Noelin has connections to neurological conditions such as schizophrenia and neurodegenerative diseases. Alterations in Noelin expression or function can disrupt synaptic connectivity potentially leading to these disorders. The protein interacts with other proteins like DISC1 in schizophrenia highlighting its importance in maintaining mental health.