Abcam, ab151727, Anti-ADRA2B antibody [EPR9623]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal ADRA2B antibody. Suitable for WB and reacts with Human samples. Cited in 12 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR9623,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ADRA2B also known as alpha-2B adrenergic receptor is a G protein-coupled receptor with an approximate mass of 50 kDa. It is specifically involved in the regulation of neurotransmitter release playing a critical role in the sympathetic nervous system. The receptor is expressed in several tissues including the brain heart and lungs. It has a high affinity for catecholamines and by binding to these ligands ADRA2B modulates various physiological processes.
Biological function summary
The alpha-2B adrenergic receptor is involved in mediating vasoconstriction and neurotransmission. This receptor is part of a larger complex of adrenergic receptors which includes alpha-2A and alpha-2C subtypes. Through its activity ADRA2B influences cardiovascular functions by controlling blood vessel tone and cardiac output. The receptor also plays roles in the central nervous system by affecting neurotransmitter release which impacts stress and arousal responses.
Pathways
The alpha-2B adrenergic receptor participates in the adrenergic signaling pathway influencing cardiovascular and nervous system activities. In this pathway it is associated with G protein interactions leading to inhibition of adenylate cyclase and reduction of cAMP levels. ADRA2B also interacts with proteins such as Giα subunits which further disseminate signals involved in the regulation of physiological responses like heart rate and vascular resistance.
The alpha-2B adrenergic receptor has links with cardiovascular diseases and psychiatric disorders. Dysregulation or mutations in ADRA2B may contribute to conditions like hypertension by affecting vasoconstriction and cardiovascular stability. Additionally alterations in receptor function could relate to mood disorders such as depression due to its role in neurotransmitter regulation. ADRA2B interacts with other adrenergic receptors and neurotransmitter systems influencing the pathophysiology of these diseases.