Abcam, ab152132, Anti-SAP102 antibody

Size: 100µL
Rabbit Polyclonal SAP102 antibody. Suitable for WB, ICC/IF, IHC-P, IHC-Fr and reacts with Mouse, Human, Rat samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human DLG3 aa 500 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human, Rat,
Applications:IHC-Fr, IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human DLG3 aa 500 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q92796

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SAP102 also known as DLG3 is a member of the membrane-associated guanylate kinase (MAGUK) protein family. This protein weighs approximately 97 kDa and is mainly expressed in the brain. SAP102 plays a significant role in signal transduction by organizing synaptic signaling complexes. It contains PDZ domains that facilitate protein-protein interactions and its expression in neuronal synapses is notable.
Biological function summary
The interaction between SAP102 and N-methyl-D-aspartate (NMDA) receptors has major implications in synapse development and plasticity. SAP102 forms part of the postsynaptic density (PSD) complex which contributes to synaptic organization and dynamics. This complex is essential for the correct functioning of synaptic signaling pathways influencing learning and memory processes.
Pathways
The regulation of synaptic plasticity and neurotransmitter release involves SAP102. In this context it plays a part in the NMDA receptor signaling pathway and the synaptic vesicle cycle. SAP102 is associated with proteins such as PSD95 and SAP97 which work together to modulate synaptic strength and communication.
Abnormalities in SAP102 function or expression have links to neurodevelopmental disorders like intellectual disability and autism spectrum disorder. Mutations in SAP102 and related proteins such as neuroligins or neurexins can disrupt synaptic communication leading to defective neural circuit formation. Understanding SAP102's role in these disorders offers insights into potential therapeutic approaches.