Abcam, ab152371, Recombinant Human Estrogen Related Receptor gamma protein

Size: 10µg
Recombinant Human Estrogen Related Receptor gamma protein is a Human Full Length protein, in the 1 to 435 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:SDS-PAGE, WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:P62508,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Estrogen Related Receptor gamma (ERRγ) also known as NR3B3 is a nuclear receptor that functions as a transcription factor. This protein regulates gene expression by binding to specific DNA sequences. ERRγ has a mass of approximately 51 kDa. It is expressed in various tissues including the heart skeletal muscle brain kidney and liver. As an orphan receptor ERRγ does not have a known endogenous ligand which impacts how it responds to different cellular signals.
Biological function summary
ERRγ influences several important physiological processes. This receptor is involved in energy metabolism mitochondrial biogenesis and cellular differentiation. ERRγ often operates as part of a larger transcriptional regulatory complex interacting with co-regulators such as PGC-1α to modulate its activity. By binding to specific genes ERRγ modulates processes like glucose metabolism fatty acid oxidation and oxidative phosphorylation which are vital for cellular energy homeostasis.
Pathways
ERRγ plays a significant role in the regulation of energy homeostasis and mitochondrial function. It is an important player in the PGC-1α signaling pathway influencing the expression of genes involved in mitochondrial biogenesis and respiration. ERRγ interacts closely with Peroxisome Proliferator-Activated Receptor (PPAR) pathways enhancing the transcription of genes required for fatty acid metabolism. These interactions contribute to the adaptive response of cells to changes in energy demands and nutrient availability.
ERRγ associates with metabolic conditions and neurodegenerative diseases. Abnormal ERRγ activity has links to metabolic syndrome which includes obesity and diabetes highlighting its role in energy metabolism and insulin sensitivity. Additionally ERRγ expression changes in neurodegenerative disorders like Alzheimer's disease where it interacts with proteins like PGC-1α and influences neuronal survival and function. Understanding these associations might offer new therapeutic targets for managing these diseases.