Abcam, ab153069, Recombinant Human TLR6 protein

Size: 10µg
Recombinant Human TLR6 protein is a Human Fragment protein, in the 201 to 300 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q9Y2C9,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Toll-like receptor 6 (TLR6) acts as an important component of the innate immune system. TLR6 is alternatively known as CD286 and has an approximate molecular mass of 91 kDa. This protein is predominantly expressed in immune cells such as monocytes dendritic cells and macrophages. It localizes mainly on the cell surface and is involved in recognizing pathogen-associated molecular patterns specifically diacyl lipopeptides and peptidoglycans.
Biological function summary
TLR6 plays a role in pathogen recognition and activation of inflammatory responses. It often forms a functional heterodimer with TLR2 a necessity for its function. Through this complex TLR6 mediates the recognition of bacterial lipoproteins and triggers downstream signaling involved in immune cell activation and cytokine production. This signaling increases the host's immune response to bacterial infections by promoting the release of pro-inflammatory cytokines.
Pathways
TLR6 initiates signaling cascades that are significant in the immune system such as the NF-kB and MAPK pathways. TLR6 partners with TLR2 to activate the MyD88-dependent signaling pathway an important pathway in innate immunity that affects transcription of pro-inflammatory genes. Interaction with these pathways involves proteins like MyD88 and TRAF6 which are central components in signal transduction leading to inflammation and antimicrobial responses.
TLR6 contributes to the pathogenesis of inflammatory and autoimmune diseases. Research indicates its association with conditions like rheumatoid arthritis and asthma where it influences inflammation levels and immune system dysregulation. TLR6 through its interaction with TLR2 affects the differentiation and activation of immune cells leading to overactive immune responses observed in these disorders. Its role in inflammation makes it a potential target for therapeutic intervention in diseases related to immune system dysfunction.