Abcam, ab153703, Anti-EML1 antibody - C-terminal

Size: 100µL
Rabbit Polyclonal EML1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human EML1 aa 550 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human EML1 aa 550 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O00423

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein known as EML1 or Echinoderm microtubule-associated protein-like 1 plays an important role in microtubule dynamics. EML1 assists in stabilizing and organizing microtubules which are cellular structures essential for cell shape division and intracellular transport. The protein has a molecular weight around 130 kDa. Researchers have found EML1 expression in various tissues including the brain where it contributes to the regulation of neuronal functions.
Biological function summary
EML1 interacts with microtubule networks supporting cellular architecture and processes such as mitosis and vesicle transport. This protein may integrate into larger protein complexes that modulate microtubule stability and dynamics. It also helps modulate intracellular signaling pathways which are critical for maintaining cellular homeostasis and development.
Pathways
EML1 participates in microtubule-associated pathways. It interacts with key proteins involved in these pathways such as tubulins to contribute to cell proliferation and differentiation. EML1 might engage in pathways like the MAPK signaling pathway where its microtubule-stabilizing function aids cell cycle regulation and growth factor signaling.
Researchers have linked EML1 mutations to brain malformations and developmental disorders such as microlissencephaly. Disruptions in its function may interfere with neuronal migration and cortical development contributing to these conditions. EML1 shows associations with proteins like LIS1 a dynein-interacting protein highlighting its potential role in neurodevelopmental diseases.