Abcam, ab153814, Anti-TMED4 antibody

Size: 100µL
Rabbit Polyclonal TMED4 antibody. Suitable for WB, ICC/IF, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TMED4 aa 1 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TMED4 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q7Z7H5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TMED4 also known as Transmembrane Emp24 Domain-Containing Protein 4 is a protein with a mass of approximately 25 kDa. It belongs to the p24 family of proteins that are involved in vesicle trafficking within cells. TMED4 is an integral membrane protein primarily located in the endoplasmic reticulum and Golgi apparatus where it participates in the transport of cargo molecules. It plays a role in facilitating the movement of proteins and lipids between organelles within the secretory pathway.
Biological function summary
The Transmembrane Emp24 Domain-Containing Protein 4 is part of a larger complex essential for the proper sorting and packaging of cargo proteins. By functioning as a scaffold TMED4 assists in maintaining the integrity of protein complexes during their transit through cellular compartments. Its expression is not restricted to a specific cell type; rather it is found ubiquitously across various tissues which suggests an important function in diverse cellular processes.
Pathways
TMED4 functions in the secretory pathway and ER-to-Golgi transport. It is integral in the regulation of vesicle formation budding and fusion events connecting with protein partners such as TMED9. These interactions play a role in processes like protein glycosylation and folding which are vital elements of cellular homeostasis. TMED4's role in these pathways highlights its importance in maintaining cellular function and protein processing.
Transmembrane Emp24 Domain-Containing Protein 4 has been implicated in disorders such as cancer and neurodegenerative diseases. Alterations in its function can disrupt normal vesicle trafficking potentially leading to an accumulation of misfolded proteins. This disruption has associations with proteins like p53 in cancer where altered protein transport can influence cell proliferation. Similarly it connects with pathways involved with amyloid precursor protein in Alzheimer's disease illustrating its relationship to the development and progression of such conditions.