Abcam, ab153841, Anti-FES antibody

Size: 100µL
Rabbit Polyclonal FES antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human FES aa 400 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human FES aa 400 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P07332

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The FES protein also known as Feline Sarcoma Oncogene is a cytoplasmic tyrosine kinase with a molecular mass of approximately 93 kDa. It plays a role in regulating processes like cell growth differentiation and survival. FES is mainly expressed in hematopoietic cells endothelial cells and some neural tissues. Its structure includes SH2 and SH3 domains allowing the protein to interact with other cellular components.
Biological function summary
FES protein is involved in signal transduction pathways that control various physiological functions. It does not form part of any giant complexes rather it serves as a relay point for signals in cellular contexts. The kinase activity of FES is important for ensuring cellular processes such as actin remodeling an important process for cell movement and shape changes.
Pathways
The FES protein participates in the RAS and MAPK signaling pathways. These pathways are important for transmitting extracellular signals that govern cell fate decisions. FES interacts with proteins such as GRB2 and SOS1 in these pathways to modulate downstream effects and enable effective response to cellular stimuli.
Aberrant FES signaling has links to cancer and inflammatory disorders. Dysregulation of FES can contribute to several types of cancer including leukemia due to its effect on cell proliferation and survival. In inflammation FES interaction with proteins like STAT3 may promote pathological inflammatory responses therefore implicating FES in diseases such as rheumatoid arthritis.