Abcam, ab153904, Anti-HOXC10 antibody

Size: 100µL
Rabbit Polyclonal HOXC10 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 30 publications. Immunogen corresponding to Recombinant Fragment Protein within Human HOXC10 aa 1 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human HOXC10 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9NYD6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.025% Proclin 300Constituents: PBS, 20% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HOXC10 also known as Homeobox C10 is a transcription factor that plays an important role in the regulation of gene expression. This protein weighing approximately 37 kDa belongs to the homeobox family and is involved in morphogenesis specifically in the development of the limbs and axial skeleton. Researchers have identified its expression in various tissues including the central nervous system and skeletal muscle. The presence of HOXC10 in these areas suggests its involvement in complex developmental processes and its importance in proper structural formation.
Biological function summary
HOXC10 participates in regulating cell differentiation and proliferation. It acts as a transcriptional regulator and part of the homeobox gene family which functions in determining cell fate and positional development. This factor does not function alone; it forms complexes with other proteins to exert its effects on target genes. By regulating the expression of other genes it supports the establishment of specific cellular phenotypes necessary for proper tissue and organ development.
Pathways
HOXC10 interacts with multiple signaling pathways including the Wnt and Hedgehog pathways which are critical for development and growth. In the Wnt pathway HOXC10 collaborates with other homeobox genes to influence gene expression necessary for proper cell positioning. It also relates closely with other HOX proteins such as HOXA1 and HOXD10 coordinating complex regulation processes that guide embryonic development and patterning.
HOXC10 has connections to several pathological conditions including cancers and neurological disorders. Aberrant expression of HOXC10 has been linked with breast cancer where it is believed to promote cancer cell proliferation and survival. Additionally changes in HOXC10 expression are associated with developmental disorders involving skeletal and neural defects. Proteins like HOXB7 and HOXD13 interact with HOXC10 showing their involvement in the regulation of pathways that when disrupted may lead to disease states. Understanding its role better could offer insights into targeted therapies for these conditions.