Abcam, ab153920, Anti-SLC17A5 antibody

Size: 100µL
Rabbit Polyclonal SLC17A5 antibody. Suitable for WB, ICC/IF, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SLC17A5 aa 1-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SLC17A5 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.Q9NRA2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SLC17A5 also known as sialin is a protein encoded by the SLC17A5 gene. It is a lysosomal membrane protein with an approximate molecular mass of 55 kDa. This protein facilitates the transport of sialic acid from the lysosome to the cytoplasm following degradation of sialoglycoconjugates. It gets expressed in various tissues with highest expression levels noted in the brain and kidneys.
Biological function summary
The protein moves sialic acid a type of acidic sugar out of lysosomes important for cellular homeostasis. SLC17A5 transports not only free sialic acid but also ascorbate and other organic anions contributing to lysosomal function regulation. Though SLC17A5 functions mainly in lysosomes it can associate with membrane complexes that regulate ion transport across membranes.
Pathways
SLC17A5 is significant within lysosomal catabolism and membrane transport pathways. In these pathways it interacts with key proteins like neuraminidase which is involved in breaking down sialoglycoconjugates. The function of sialin in moving sialic acid affects these metabolic pathways and has an impact on maintaining cellular balance.
SLC17A5 has ties to free sialic acid storage disorders notably Salla disease and infantile sialic acid storage disorder (ISSD). These are neurodegenerative disorders linked to sialic acid accumulation caused by SLC17A5 malfunction. Mutations in this gene affect its transport function leading to these diseases. Additionally SLC17A5 relates to metabolic disorders by interacting with other transmembrane proteins potentially influencing disease progression.