Abcam, ab153947, Anti-FOXB1 antibody - C-terminal

Size: 100µL
Rabbit Polyclonal FOXB1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human FOXB1 aa 250 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human FOXB1 aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q99853

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FOXB1 also known as Forkhead box protein B1 is a transcription factor. It typically weighs around 75 kDa. FOXB1 expression predominantly occurs in the brain where it regulates gene expression critical for development and function. This protein binds to DNA influencing the transcription of target genes which plays a role in development processes.
Biological function summary
FOXB1 influences nervous system development and function acting as part of a complex that modulates transcriptional activity. Its role extends to maintaining cellular proliferation and differentiation. FOXB1's interaction with specific DNA elements shows its contribution to neurogenesis and axonal guidance which are essential for proper brain structure and function.
Pathways
FOXB1 operates within the Hedgehog and Wnt signaling pathways which are essential for cell fate determination and growth in the brain. It works alongside proteins such as Gli in the Hedgehog signaling pathway to influence developmental processes. In the Wnt signaling pathway FOXB1 interacts with beta-catenin-related functions important for synaptic and neuronal activities in the brain.
FOXB1's involvement relates to neurodevelopmental disorders and glioblastoma. Altered FOXB1 expression or function can contribute to improper brain development leading to neurodevelopmental issues. In glioblastoma FOXB1 interacts with FoxG1 suggesting roles in tumor progression. Studying FOXB1 interactions offers insights into potential therapeutic targets for these conditions.