Abcam, ab154086, Anti-TTLL12 antibody

Size: 100µL
Rabbit Polyclonal TTLL12 antibody. Suitable for IHC-P, WB and reacts with Human, Mouse samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TTLL12 aa 400 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TTLL12 aa 400 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q14166

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TTLL12 also known as Tubulin Tyrosine Ligase Like 12 is an enzyme that belongs to the tubulin tyrosine ligase-like (TTLL) family. This protein functions mechanically by catalyzing the polyglutamylation of target proteins especially tubulin impacting microtubule stability and interaction. TTLL12 has a mass of approximately 60 kDa and is predominantly expressed in the brain and testis although its expression is noted in other tissues as well. The involvement of TTLL12 in these tissues suggests its significance in specialized cellular processes.
Biological function summary
TTLL12 influences neuronal and cellular functions through its capacity to alter the microtubule network. It participates in the polyglutamylation activity that regulates microtubule dynamics synaptic stability and intracellular transport playing critical roles in neurodevelopment and cellular organization. Although TTLL12 itself does not commonly form large complexes its enzymatic activity impacts other microtubule-modifying complexes indirectly affecting cellular architecture and signaling pathways.
Pathways
TTLL12 participates notably in the microtubule-network pathway and the regulation of cytoskeleton organization. Its activity modulates the polymerization and depolymerization dynamics of microtubules impacting cell cycle and neuronal signaling. TTLL12's function is related to other tubulin-modifying enzymes such as TTLL1 and TTLL5 which share a role in tubulin modification thereby affecting cellular processes like mitosis and intracellular trafficking.
TTLL12's aberrant activity or expression has connections to neurodegenerative diseases and male infertility. For example its dysfunction in the brain is associated with tauopathies where improper microtubule regulation contributes to disease pathology. Additionally TTLL12's function relates to proteins like tau and other microtubule-associated proteins (MAPs) which play roles in maintaining neuronal structure and function. Understanding its connections to these conditions may shed light on potential therapeutic strategies.