Abcam, ab154157, Anti-GNA15 antibody

Size: 100µL
Rabbit Polyclonal GNA15 antibody. Suitable for WB, ICC/IF and reacts with Transfected cell lysate, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human GNA15 aa 100 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human GNA15 aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P30679

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein GNA15 also known as G-protein subunit alpha-15 functions as part of the G protein complex which transduces signals from G protein-coupled receptors (GPCRs) to intracellular effectors. This protein weighs approximately 43 kDa. GNA15 gets expressed in various cell types with a notably higher expression in immune cells like lymphocytes and monocytes. Its role is to facilitate the transduction of external signals into a cellular response contributing to the regulation of numerous physiological processes.
Biological function summary
GNA15 participates in signal transduction by interacting with a range of signaling molecules. This protein serves as a mediator that couples activated GPCRs to downstream effectors influencing cellular responses. GNA15 does not operate alone; it forms a part of a heterotrimeric complex composed of alpha beta and gamma subunits enabling the integration of signals that modulate cellular activities like proliferation differentiation and immune response.
Pathways
GNA15 actively participates in intracellular signaling pathways that are critical for immune responses and cellular communication. The protein gets involved in the phospholipase C (PLC) pathway linking it with inositol trisphosphate (IP3) and diacylglycerol (DAG) production. Within this pathway it interacts with other proteins such as PLC-beta which play key roles in signal transduction. Furthermore GNA15 associates with the mitogen-activated protein kinase (MAPK) pathway impacting cell growth and survival.
GNA15 has connections to conditions involving immune function and inflammation. Aberrations in its signaling pathway have been implicated in immune disorders and inflammatory diseases such as rheumatoid arthritis. Additionally GNA15 links with other proteins like PLC-beta in the context of inflammatory signal transduction highlighting its importance in disease etiology and potential as a therapeutic target.