Abcam, ab154172, Anti-RGS10 antibody [EPR10657(B)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal RGS10 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR10657(B),
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
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contact us
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Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RGS10 also known as Regulator of G-protein Signaling 10 is a 20 kDa protein that regulates G-protein signaling. This protein accelerates the GTPase activity of the G alpha subunits leading to termination of the G-protein signaling. RGS10 expresses mainly in the brain and immune cells where it modulates signal transduction processes. It influences cellular responses significantly due to its ability to deactivate active G-proteins by increasing their GTPase activity.
Biological function summary
RGS10 plays a role in immune responses and neural function. It is not typically part of larger protein complexes but it interacts independently with other proteins in cellular signaling pathways. In the immune system RGS10 influences various processes such as cytokine production and leukocyte function. In neurons RGS10 contributes to maintaining neural signaling by regulating neurotransmitter-related G-protein coupled receptor pathways.
Pathways
G-protein signaling pathways and the MAPK signaling pathway include RGS10 as an important regulatory protein. It modulates the G-protein coupled receptor signaling pathway an important aspect of cellular response to external stimuli. RGS10 also influences the PI3K-Akt signaling pathway by regulating upstream signaling events. These pathways involve proteins such as G alpha subunits and PI3 kinase which interact with RGS10 to control diverse physiological processes.
Individuals with altered RGS10 expression may have neurodegenerative diseases and inflammatory disorders. Alzheimer's disease is one condition where RGS10's regulatory control affects neuronal cell survival and tau phosphorylation a process implicated in disease progression. Regarding inflammation its interaction with NLRP3 inflammasome proteins connects RGS10 to inflammatory pathways which can lead to disorders like rheumatoid arthritis. Adjusting RGS10 levels might modulate disease mechanisms highlighting its potential therapeutic interest.