Abcam, ab154258, Anti-APIP antibody

Size: 100µL
Rabbit Polyclonal APIP antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human APIP aa 1 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human APIP aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q96GX9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
APIP also known as APAF1-interacting protein weighs around 26 kDa and serves as an anti-apoptotic factor. This protein is widely expressed in various tissues including the liver brain and heart. Mechanically APIP regulates apoptosis by interacting with APAF1 which prevents the activation of the apoptosome. The inhibition of apoptosis helps cells survive under stress conditions.
Biological function summary
APIP plays a significant role in modulating the cellular mechanism of apoptosis. As part of the apoptosis inhibition complex it interacts with APAF1 to control programmed cell death. Additionally APIP contributes to cell survival during oxidative stress by modulating the methionine salvage pathway and maintaining cellular redox balance.
Pathways
APIP integrates into essential cellular systems such as the apoptosis and methionine salvage pathways. By interacting with APAF1 in the apoptotic pathway APIP directly influences the intrinsic pathway of apoptosis. At the same time it connects with enzymes involved in methionine metabolism supporting cellular survival mechanisms through antioxidant defense.
APIP shows a connection to cancer and ischemic injury. In cancer APIP confers resistance to apoptosis promoting tumor survival even under cellular stress. Its interaction with APAF1 plays an important role in this mechanism. In ischemic conditions APIP involvement in the methionine salvage pathway helps prevent oxidative damage by supporting cellular redox balance potentially linking it to proteins involved in ischemic protection.