Abcam, ab154318, Anti-MAFG antibody

Size: 100µL
Rabbit Polyclonal MAFG antibody. Suitable for IP, IHC-P, WB, ICC/IF and reacts with Human, Mouse, Rat samples. Cited in 12 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MAFG aa 1 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, ICC/IF, WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MAFG aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O15525

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.025% Proclin 300Constituents: PBS, 20% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MAFG also known as MAFG transcription factor is a small basic leucine zipper (bZIP) protein that weighs approximately 18 kDa. It belongs to the small MAF protein family and has a role in gene regulation. MAFG is widely expressed in various tissues but shows higher expression in the liver and lungs. Functionally MAFG acts as a transcriptional repressor by binding to Maf recognition elements (MAREs) in the DNA regulating genes involved in cellular stress responses and homeostasis.
Biological function summary
The MAFG transcription factor forms complexes with other small MAF proteins like MAFF and MAFK or larger bZIP proteins. These complexes modulate transcription of antioxidant response genes such as those encoding phase II detoxifying enzymes. MAFG is important for the regulation of oxidative stress genes. The interaction of MAFG with other proteins determines whether it functions as a repressor or an activator influencing cellular responses to various stimuli.
Pathways
MAFG plays an important role in the oxidative stress response and the Nrf2 signaling pathway. It interacts closely with Nrf2 an important transcription factor activating the expression of antioxidant proteins to protect against oxidative damage. MAFG and Nrf2 along with other proteins facilitate cellular defense mechanisms by maintaining redox balance and regulating detoxification processes.
MAFG links to conditions such as cancer and neurodegenerative diseases. Aberrant expression of MAFG may contribute to tumor development and progression by disrupting cellular homeostasis and detoxification pathways. Additionally MAFG dysregulation can affect the Nrf2 pathway impacting neurodegenerative disorders like Alzheimer's disease. Therefore understanding MAFG's interaction with Nrf2 and other proteins can provide insights into therapeutic strategies targeting these diseases.