Abcam, ab154496, Anti-MMP19 antibody

Size: 100µL
Rabbit Polyclonal MMP19 antibody. Suitable for WB, IHC-P and reacts with Transfected cell line, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MMP19 aa 200-500.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MMP19 aa 200-500. The exact immunogen used to generate this antibody is proprietary information.Q99542

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MMP19 also known as Matrix Metalloproteinase 19 is an enzyme that plays a role in the breakdown of extracellular matrix components. The protein has a molecular weight of approximately 54 kDa. MMP19 is expressed in various tissues including the skin lung and cartilage. It participates in the remodeling of the extracellular matrix which is significant for processes such as tissue repair and embryonic development.
Biological function summary
MMP19 contributes to cellular processes by modulating the extracellular environment and interacting with other matrix proteins. It does not usually appear as a part of large complexes but may influence the behavior of cell migration proliferation and differentiation. Its action helps in regulating cellular responses to their environment which emphasizes its involvement in maintaining tissue homeostasis.
Pathways
MMP19 is associated with the extracellular matrix degradation pathway which is essential for tissue remodeling. It also interacts with signaling molecules in the MAPK pathway that integrate external signals into various cellular responses. Through these pathways MMP19 relates to other matrix metalloproteinases such as MMP2 and MMP9 contributing to coordinated extracellular matrix turnover.
Involvement of MMP19 is significant in cancer progression and rheumatoid arthritis. In cancer abnormal expression of MMP19 can lead to increased invasion and metastasis by degrading the extracellular matrix barriers. In rheumatoid arthritis MMP19 contributes to the breakdown of joint cartilage exacerbating the disease. MMP19's relationship with proteins like tissue inhibitors of metalloproteinases (TIMPs) further influences these disease processes by balancing its proteolytic activity.