Abcam, ab154637, Anti-PHF10 antibody

Size: 100µL
Rabbit Polyclonal PHF10 antibody. Suitable for WB, ICC/IF, IHC-P and reacts with Mouse, Human, Rat samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PHF10 aa 200 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human, Rat,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PHF10 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q8WUB8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.025% Proclin 300Constituents: PBS, 20% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PHF10 also known as PHD finger protein 10 plays a mechanistic role in chromatin remodeling and gene expression. It exhibits a molecular weight of approximately 50 kDa. Researchers have identified PHF10 as a component of the BAF (BRG1-associated factor) chromatin remodeling complex. It is widely expressed in various tissues including the brain where it contributes to neural development and function. Its expression can have tissue-specific variations that reflect its diverse roles in different cellular contexts.
Biological function summary
PHD finger protein 10 participates in the regulation of gene transcription and chromatin architecture. It functions as part of the BAF complex which orchestrates the dynamic remodeling of chromatin to either activate or repress specific genes. This action facilitates cellular processes like differentiation proliferation and response to environmental signals. PHF10 through its interaction with other BAF complex components influences the accessibility of DNA to transcription factors and other regulatory proteins thereby modulating gene expression patterns in cells.
Pathways
PHF10 integrates into the Wnt signaling pathway which is important for cell proliferation and differentiation as well as the Hedgehog signaling pathway important for developmental processes. Within these pathways PHF10 collaborates closely with proteins such as SMARCA4 a core ATPase subunit of the BAF complex. These pathways play fundamental roles in ensuring proper development and maintaining cellular homeostasis where PHF10 activity impacts both normal cellular function and response to environmental changes.
Dysregulation of PHF10 function associates with neurodevelopmental disorders and certain forms of cancer. Altered PHF10 expression or mutations can disrupt normal chromatin remodeling activities leading to improper gene expression profiles. In the context of neurodevelopmental disorders PHF10 misfunction can impact genes critical for nervous system development. In some cancers abnormal interactions between PHF10 and proteins like SMARCC1 another BAF complex member can result in the derangement of gene regulatory networks therefore promoting oncogenic processes.