Abcam, ab154790, Anti-DHHC-18 antibody [EPR9871]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal DHHC-18 antibody. Suitable for IHC-P, WB and reacts with Human, Mouse, Rat samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR9871,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DHHC-18 also known as ZDHHC18 functions as a palmitoyltransferase enzyme responsible for the addition of palmitate a type of lipid to target proteins. This process is known as palmitoylation and it influences the proteins' membrane association and function. DHHC-18 has a molecular weight of about 41 kDa. Expression of DHHC-18 occurs in various tissues including the brain and heart implicating its role in diverse cellular processes.
Biological function summary
DHHC-18 contributes to protein trafficking and signaling by influencing the membrane dynamics. It does not act alone but as part of a large dynamic network of proteins regulating lipid modifications. This network helps in processes such as synaptic signaling and neuronal growth highlighting its importance in neurobiology. Through its catalytic activity DHHC-18 can modify substrates like Ras-related proteins affecting their functional states and interactions.
Pathways
DHHC-18 interacts within the Ras signaling and synaptic transmission pathways. Through its involvement in Ras signaling DHHC-18 modulates the activity of Ras proteins which contributes to cell growth and differentiation. Furthermore the synaptic transmission pathway gets influenced by this palmitoylation enzyme affecting neurotransmitter release with interacting proteins like PSD-95 playing key roles in maintaining synaptic plasticity and stability.
DHHC-18 has implications in neurological conditions such as schizophrenia and autism spectrum disorders. Its direct connection involves the modulation of neuronal membrane proteins important for proper brain function. Abnormal palmitoylation due to DHHC-18 dysfunction can disrupt the balance of synaptic signaling leading to cognitive and behavioral anomalies. Dysregulation can also influence proteins like NLGN3 and CNTNAP2 which are pivotal in psychiatric and neurodevelopmental disorders.